Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2654658..2655229 Replicon chromosome
Accession NZ_CP061368
Organism Wenzhouxiangella sp. AB-CW3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IC757_RS11580 Protein ID WP_190974468.1
Coordinates 2654658..2654936 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IC757_RS11585 Protein ID WP_190974469.1
Coordinates 2654945..2655229 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC757_RS11550 2649806..2650213 - 408 WP_190974462.1 FHA domain-containing protein -
IC757_RS11555 2650365..2651378 - 1014 WP_190974463.1 tRNA pseudouridine(13) synthase TruD -
IC757_RS11560 2651508..2651942 - 435 WP_190974464.1 hypothetical protein -
IC757_RS11565 2652074..2652952 - 879 WP_190974465.1 winged helix-turn-helix domain-containing protein -
IC757_RS11570 2653093..2653377 - 285 WP_190974466.1 septum formation initiator family protein -
IC757_RS11575 2653387..2654532 - 1146 WP_190974467.1 succinyl-diaminopimelate desuccinylase -
IC757_RS11580 2654658..2654936 + 279 WP_190974468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IC757_RS11585 2654945..2655229 + 285 WP_190974469.1 HigA family addiction module antidote protein Antitoxin
IC757_RS11590 2655332..2655499 - 168 WP_190974470.1 hypothetical protein -
IC757_RS11595 2655741..2656511 + 771 WP_190974471.1 zinc-dependent peptidase -
IC757_RS11600 2656609..2657022 - 414 WP_190974472.1 MGMT family protein -
IC757_RS11605 2656964..2657713 - 750 WP_190974473.1 RNA methyltransferase -
IC757_RS11610 2657771..2659822 - 2052 WP_190974474.1 prolyl oligopeptidase family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10496.05 Da        Isoelectric Point: 10.2791

>T172499 WP_190974468.1 NZ_CP061368:2654658-2654936 [Wenzhouxiangella sp. AB-CW3]
MIRSFACDETRKLFETGKSRRFSSIAKVALRKLDQLDNVTQPRSLATPPGNCLEALKGNRIGQFSIRINKQLRVCFRWSD
NGPEGVEIVDYH

Download         Length: 279 bp

>T172499 NZ_CP079770:4305773-4306180 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10704.25 Da        Isoelectric Point: 7.4053

>AT172499 WP_190974469.1 NZ_CP061368:2654945-2655229 [Wenzhouxiangella sp. AB-CW3]
MNRVTTHPGEMLLEEFMVPLGLSARALARALDVPHNRISELVAGRRSMTADTAVRLERYFGMEARFWLNLQTAHDLSRTR
AEGDFEHIKPREAA

Download         Length: 285 bp

>AT172499 NZ_CP079770:4305526-4305792 [Escherichia coli]
ATGGACATTAACAGCAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References