Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1689004..1689551 Replicon chromosome
Accession NZ_CP061368
Organism Wenzhouxiangella sp. AB-CW3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IC757_RS07330 Protein ID WP_190976683.1
Coordinates 1689297..1689551 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag IC757_RS07325 Protein ID WP_190976682.1
Coordinates 1689004..1689297 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC757_RS07305 1684347..1684778 + 432 WP_190976679.1 hypothetical protein -
IC757_RS07310 1684848..1687532 + 2685 WP_190976680.1 tetratricopeptide repeat protein -
IC757_RS07315 1687572..1688168 + 597 WP_190976681.1 sigma-70 family RNA polymerase sigma factor -
IC757_RS07320 1688352..1688762 - 411 WP_190976971.1 GNAT family N-acetyltransferase -
IC757_RS07325 1689004..1689297 - 294 WP_190976682.1 HigA family addiction module antidote protein Antitoxin
IC757_RS07330 1689297..1689551 - 255 WP_190976683.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IC757_RS07335 1690025..1690396 - 372 WP_190976684.1 hypothetical protein -
IC757_RS07340 1690612..1691253 + 642 Protein_1435 IS4 family transposase -
IC757_RS07345 1691384..1692910 + 1527 WP_190976685.1 IS21 family transposase -
IC757_RS07350 1692897..1693637 + 741 WP_190974040.1 IS21-like element helper ATPase IstB -
IC757_RS07355 1693700..1694233 + 534 Protein_1438 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-84)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9679.94 Da        Isoelectric Point: 6.8783

>T172496 WP_190976683.1 NZ_CP061368:c1689551-1689297 [Wenzhouxiangella sp. AB-CW3]
VLAKFYETGSVAGVQPSHAKRLRMLLAALDTAASIQDMDVPGFRLHRLKGMDADRWSIRVSENWRLTYEFRDGQAHVVDY
EDYH

Download         Length: 255 bp

>T172496 NZ_CP079770:4146726-4147103 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCGGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGGCATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11117.73 Da        Isoelectric Point: 6.8705

>AT172496 WP_190976682.1 NZ_CP061368:c1689297-1689004 [Wenzhouxiangella sp. AB-CW3]
MSMHNPPHPGEFIREVYLEPHSMTGRQLASKLCVSPSTLNRILQERSGISPEMALRLSKALGRSPESWLLMQDNYELWHA
RQTVDLESVEKVEFRAA

Download         Length: 294 bp

>AT172496 NZ_CP079770:4146268-4146636 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAAGACAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCCTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References