Detailed information of TA system TA172495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1568196..1568828
• Replicon: chromosome
• Accession: NZ_CP061368
• Organism: Wenzhouxiangella sp. AB-CW3

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: IC757_RS06780
• Protein ID: WP_190976590.1
• Coordinates: 1568196..1568477 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IC757_RS06785
• Protein ID: WP_190976591.1
• Coordinates: 1568532..1568828 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC757_RS06760	1563910..1565139	-	1230	WP_190976586.1	patatin-like phospholipase family protein	-
IC757_RS06765	1565195..1565644	+	450	WP_190976587.1	peroxiredoxin	-
IC757_RS06770	1565641..1566384	+	744	WP_190976588.1	hypothetical protein	-
IC757_RS06775	1566843..1567166	-	324	WP_190976589.1	GIY-YIG nuclease family protein	-
IC757_RS06780	1568196..1568477	+	282	WP_190976590.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IC757_RS06785	1568532..1568828	+	297	WP_190976591.1	HigA family addiction module antidote protein	Antitoxin
IC757_RS06790	1570664..1571338	-	675	WP_190976592.1	HAD-IA family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (7-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10978.55 Da
• Isoelectric Point: 11.0956

>T172495 WP_190976590.1 NZ_CP061368:1568196-1568477 [Wenzhouxiangella sp. AB-CW3]
MIRSFADRETRVIWEGRQSRKLPANIQATARRKLRMLNNARDLTDLRVPPGNRLEALKGNRVGQYSIRINDQWRICFKWQ
DNAAAEVEIVDYH

Nucleotide

• Length: 282 bp

>T172495 NZ_CP079770:4093163-4093477 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11234.88 Da
• Isoelectric Point: 7.3212

>AT172495 WP_190976591.1 NZ_CP061368:1568532-1568828 [Wenzhouxiangella sp. AB-CW3]
MTTDRLPNVHPGEILLEEFLKPMGISQNRLARTIEVPPRRINEIVLGKRRVTADTAMRLARAFGTSERFWLGLQADYDLE
QAHFDHGEEVRRIPNIAA

Nucleotide

• Length: 297 bp

>AT172495 NZ_CP079770:4093474-4093890 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA