Detailed information of TA system TA172471

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 34947..35216
• Replicon: plasmid pM2901
• Accession: NZ_CP061363
• Organism: Shigella sonnei strain 6207

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: IC759_RS00260
• Protein ID: WP_001372321.1
• Coordinates: 35091..35216 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	34947..35012 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC759_RS00225	30712..31239	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
IC759_RS00230	31297..31530	+	234	WP_000006003.1	DUF905 family protein	-
IC759_RS00235	31591..33559	+	1969	Protein_46	ParB/RepB/Spo0J family partition protein	-
IC759_RS00240	33628..34062	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
IC759_RS00245	34059..34778	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	34790..35014	+	225	NuclAT_0	-	-
-	34790..35014	+	225	NuclAT_0	-	-
-	34790..35014	+	225	NuclAT_0	-	-
-	34790..35014	+	225	NuclAT_0	-	-
IC759_RS00250	34799..34978	-	180	WP_001309233.1	hypothetical protein	-
-	34947..35012	-	66	-	-	Antitoxin
IC759_RS00255	35000..35149	+	150	Protein_50	plasmid maintenance protein Mok	-
IC759_RS00260	35091..35216	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
IC759_RS00265	35535..35831	-	297	Protein_52	hypothetical protein	-
IC759_RS00270	36131..36427	+	297	WP_001272251.1	hypothetical protein	-
IC759_RS00275	36538..37359	+	822	WP_001234445.1	DUF932 domain-containing protein	-
IC759_RS00280	37656..38258	-	603	WP_000243713.1	transglycosylase SLT domain-containing protein	-
IC759_RS00285	38581..38964	+	384	WP_001354030.1	conjugal transfer relaxosome DNA-binding protein TraM	-
IC759_RS00290	39158..39829	+	672	WP_000283561.1	conjugal transfer transcriptional regulator TraJ	-
IC759_RS00295	39966..40193	+	228	WP_000089263.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T172471 WP_001372321.1 NZ_CP061363:35091-35216 [Shigella sonnei]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T172471 NZ_CP079767:3636425-3636532 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT172471 NZ_CP061363:c35012-34947 [Shigella sonnei]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin