Detailed information of TA system TA172447

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2476567..2476751
• Replicon: chromosome
• Accession: NZ_CP061349
• Organism: Staphylococcus aureus strain MSSA01

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IC588_RS12360
• Protein ID: WP_000482647.1
• Coordinates: 2476644..2476751 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2476567..2476627 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC588_RS12345	2472021..2472188	-	168	WP_001792506.1	hypothetical protein	-
IC588_RS12350	2472419..2474152	-	1734	WP_000486496.1	ABC transporter ATP-binding protein/permease	-
IC588_RS12355	2474177..2475940	-	1764	WP_001064836.1	ABC transporter ATP-binding protein/permease	-
-	2476567..2476627	+	61	-	-	Antitoxin
IC588_RS12360	2476644..2476751	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
IC588_RS12365	2476885..2477271	-	387	WP_000779360.1	flippase GtxA	-
IC588_RS12370	2477529..2478671	+	1143	WP_001176863.1	glycerate kinase	-
IC588_RS12375	2478731..2479390	+	660	WP_000831295.1	hypothetical protein	-
IC588_RS12380	2479572..2480783	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IC588_RS12385	2480906..2481379	-	474	WP_000456492.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T172447 WP_000482647.1 NZ_CP061349:c2476751-2476644 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T172447 NZ_CP079762:c3236260-3235892 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT172447 NZ_CP061349:2476567-2476627 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin