Detailed information of TA system TA172445

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 2198443..2198640
• Replicon: chromosome
• Accession: NZ_CP061349
• Organism: Staphylococcus aureus strain MSSA01

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IC588_RS10910
• Protein ID: WP_001802298.1
• Coordinates: 2198536..2198640 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2198443..2198481 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC588_RS10895	2193717..2194697	+	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
IC588_RS10900	2194963..2196054	+	1092	WP_000495672.1	hypothetical protein	-
IC588_RS10905	2196083..2197728	-	1646	Protein_2107	IS1182 family transposase	-
-	2198443..2198481	+	39	-	-	Antitoxin
IC588_RS10910	2198536..2198640	-	105	WP_001802298.1	hypothetical protein	Toxin
IC588_RS10915	2199320..2199478	+	159	WP_001792784.1	hypothetical protein	-
IC588_RS10920	2200137..2200994	-	858	WP_000370931.1	Cof-type HAD-IIB family hydrolase	-
IC588_RS10925	2201062..2201844	-	783	WP_000908174.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T172445 WP_001802298.1 NZ_CP061349:c2198640-2198536 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T172445 NZ_CP079762:c2720539-2720129 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT172445 NZ_CP061349:2198443-2198481 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin