Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2198378..2198640 Replicon chromosome
Accession NZ_CP061349
Organism Staphylococcus aureus strain MSSA01

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag IC588_RS10910 Protein ID WP_001802298.1
Coordinates 2198536..2198640 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2198378..2198541 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC588_RS10890 2193395..2193715 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
IC588_RS10895 2193717..2194697 + 981 WP_000019739.1 CDF family zinc efflux transporter CzrB -
IC588_RS10900 2194963..2196054 + 1092 WP_000495672.1 hypothetical protein -
IC588_RS10905 2196083..2197728 - 1646 Protein_2107 IS1182 family transposase -
- 2198378..2198541 + 164 - - Antitoxin
IC588_RS10910 2198536..2198640 - 105 WP_001802298.1 hypothetical protein Toxin
IC588_RS10915 2199320..2199478 + 159 WP_001792784.1 hypothetical protein -
IC588_RS10920 2200137..2200994 - 858 WP_000370931.1 Cof-type HAD-IIB family hydrolase -
IC588_RS10925 2201062..2201844 - 783 WP_000908174.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T172444 WP_001802298.1 NZ_CP061349:c2198640-2198536 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T172444 NZ_CP079762:c1636715-1636613 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 164 bp

>AT172444 NZ_CP061349:2198378-2198541 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References