Detailed information of TA system TA172438

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1581909..1582488
• Replicon: chromosome
• Accession: NZ_CP061349
• Organism: Staphylococcus aureus strain MSSA01

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: IC588_RS07665
• Protein ID: WP_001025401.1
• Coordinates: 1582243..1582488 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1581909..1582274 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC588_RS07625	1578650..1579207	-	558	WP_000645045.1	DUF2815 family protein	-
IC588_RS07630	1579233..1580399	-	1167	WP_000762546.1	DUF2800 domain-containing protein	-
IC588_RS07635	1580396..1580758	-	363	WP_000985976.1	hypothetical protein	-
IC588_RS07640	1580773..1581096	-	324	WP_000174994.1	hypothetical protein	-
IC588_RS07645	1581175..1581336	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
IC588_RS07650	1581349..1581612	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
IC588_RS07655	1581639..1581854	-	216	WP_001097552.1	hypothetical protein	-
IC588_RS07660	1581909..1582274	+	366	WP_001128433.1	hypothetical protein	Antitoxin
IC588_RS07665	1582243..1582488	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
IC588_RS07670	1582555..1582935	+	381	WP_196584232.1	DUF2513 domain-containing protein	-
IC588_RS07675	1582922..1583119	-	198	WP_001148860.1	hypothetical protein	-
IC588_RS07680	1583189..1583401	+	213	WP_000362643.1	hypothetical protein	-
IC588_RS07685	1583442..1583591	-	150	WP_000771849.1	hypothetical protein	-
IC588_RS07690	1583606..1584049	-	444	WP_000435357.1	hypothetical protein	-
IC588_RS07695	1584097..1584309	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
IC588_RS07700	1584461..1585192	+	732	WP_000511090.1	XRE family transcriptional regulator	-
IC588_RS07705	1585263..1585445	+	183	WP_000705240.1	hypothetical protein	-
IC588_RS07710	1585483..1585629	+	147	WP_001794606.1	hypothetical protein	-
IC588_RS07715	1585626..1586240	-	615	WP_031901849.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1541657..1599554	57897

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T172438 WP_001025401.1 NZ_CP061349:c1582488-1582243 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T172438 NZ_CP079759:507414-507764 [Bacillus sp. LJBS17]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT172438 NZ_CP061349:1581909-1582274 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin