Detailed information of TA system TA172437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1573051..1573465
• Replicon: chromosome
• Accession: NZ_CP061349
• Organism: Staphylococcus aureus strain MSSA01

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IC588_RS07565
• Protein ID: WP_001065046.1
• Coordinates: 1573214..1573465 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IC588_RS07560
• Protein ID: WP_000028424.1
• Coordinates: 1573051..1573224 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC588_RS07520	1568551..1568841	-	291	WP_000665205.1	VRR-NUC domain-containing protein	-
IC588_RS07525	1568975..1569079	+	105	WP_001802079.1	hypothetical protein	-
IC588_RS07530	1569182..1571629	-	2448	WP_000884844.1	virulence-associated E family protein	-
IC588_RS07535	1571681..1571881	-	201	WP_000265258.1	DUF1514 family protein	-
IC588_RS07540	1571949..1572101	-	153	WP_000595272.1	transcriptional activator RinB	-
IC588_RS07545	1572098..1572304	-	207	WP_111743877.1	DUF1381 domain-containing protein	-
IC588_RS07550	1572341..1572874	-	534	WP_001061838.1	dUTP diphosphatase	-
IC588_RS07555	1572889..1573050	-	162	WP_000889684.1	hypothetical protein	-
IC588_RS07560	1573051..1573224	-	174	WP_000028424.1	hypothetical protein	Antitoxin
IC588_RS07565	1573214..1573465	-	252	WP_001065046.1	DUF1024 family protein	Toxin
IC588_RS07570	1573458..1573869	-	412	Protein_1485	acetyltransferase	-
IC588_RS07575	1573866..1574375	-	510	WP_088811208.1	hypothetical protein	-
IC588_RS07580	1574372..1574779	-	408	WP_088811209.1	hypothetical protein	-
IC588_RS07585	1574776..1575186	-	411	WP_196584230.1	hypothetical protein	-
IC588_RS07590	1575200..1575448	-	249	WP_196584231.1	hypothetical protein	-
IC588_RS07595	1575457..1575657	-	201	WP_000235326.1	hypothetical protein	-
IC588_RS07600	1575660..1575917	-	258	WP_000022728.1	DUF3310 domain-containing protein	-
IC588_RS07605	1575917..1576276	-	360	WP_000029382.1	hypothetical protein	-
IC588_RS07610	1576277..1576462	-	186	WP_001187249.1	DUF3113 family protein	-
IC588_RS07615	1576462..1576617	-	156	WP_000152769.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1541657..1599554	57897

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9377.26 Da
• Isoelectric Point: 3.7128

>T172437 WP_001065046.1 NZ_CP061349:c1573465-1573214 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T172437 NZ_CP079758:c5225323-5225045 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT172437 WP_000028424.1 NZ_CP061349:c1573224-1573051 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT172437 NZ_CP079758:c5225033-5224728 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG