Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 1097912..1098444 Replicon chromosome
Accession NZ_CP061341
Organism Lactobacillus kefiranofaciens strain 1207

Toxin (Protein)


Gene name yoeB Uniprot ID A0A656YA18
Locus tag ICI50_RS05460 Protein ID WP_013854119.1
Coordinates 1097912..1098181 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag ICI50_RS05465 Protein ID WP_188891292.1
Coordinates 1098178..1098444 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI50_RS05440 1093546..1094097 - 552 WP_013854115.1 DNA-binding protein -
ICI50_RS05445 1094097..1094327 - 231 WP_013854116.1 cation transporter -
ICI50_RS05450 1094350..1096251 - 1902 WP_188891291.1 heavy metal translocating P-type ATPase -
ICI50_RS05455 1096369..1097706 - 1338 WP_025084196.1 MATE family efflux transporter -
ICI50_RS05460 1097912..1098181 - 270 WP_013854119.1 Txe/YoeB family addiction module toxin Toxin
ICI50_RS05465 1098178..1098444 - 267 WP_188891292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ICI50_RS05470 1098695..1099498 - 804 WP_082599082.1 alpha/beta hydrolase -
ICI50_RS05475 1099555..1100724 - 1170 WP_056941351.1 PatB family C-S lyase -
ICI50_RS05480 1100730..1101623 - 894 WP_013854124.1 DUF3737 family protein -
ICI50_RS05485 1101682..1101999 - 318 WP_025084192.1 carboxymuconolactone decarboxylase family protein -
ICI50_RS05490 1102009..1102424 - 416 Protein_1039 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-67)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10617.35 Da        Isoelectric Point: 10.4670

>T172435 WP_013854119.1 NZ_CP061341:c1098181-1097912 [Lactobacillus kefiranofaciens]
MILKYHGRIKNSAKPDLKKIKRSNLKDNFQDIIDQLKKDPYKKNQGFEKLEPPILGKYSRRINIKHRVVYTVDDVNKIVS
IYSAWSHYE

Download         Length: 270 bp

>T172435 NZ_CP079758:c4300960-4300373 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.11 Da        Isoelectric Point: 4.4857

>AT172435 WP_188891292.1 NZ_CP061341:c1098444-1098178 [Lactobacillus kefiranofaciens]
MDATIYTPTGARRNLFNLIKQVNKNHIPVNIESTKDKAESAVLISKSDWDAIQETLYLESNGVGEVVRKREKDNSGFTDI
DDINWDEL

Download         Length: 267 bp

>AT172435 NZ_CP079758:c4300306-4299452 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGACAGCCTGGAAACCCAGACCCGCTGGCGTGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGTGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCATCCTTGACGATCTACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656YA18

Antitoxin

Source ID Structure

References