Detailed information of TA system TA172378

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 588432..588690
• Replicon: chromosome
• Accession: NZ_CP061337
• Organism: Escherichia coli strain M11957

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: IC756_RS02755
• Protein ID: WP_000935262.1
• Coordinates: 588432..588641 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	588633..588690 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC756_RS02735	583674..584387	-	714	WP_001102367.1	acidic protein MsyB	-
IC756_RS02740	584413..584817	-	405	WP_000843584.1	DUF2541 family protein	-
IC756_RS02745	585193..587109	+	1917	WP_000516135.1	molecular chaperone DnaK	-
IC756_RS02750	587198..588328	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
IC756_RS02755	588432..588641	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	588633..588690	+	58	-	-	Antitoxin
IC756_RS02760	589170..590336	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
IC756_RS02765	590402..591301	+	900	WP_001300855.1	transcriptional activator NhaR	-
IC756_RS02770	591339..592298	-	960	WP_000871674.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T172378 WP_000935262.1 NZ_CP061337:c588641-588432 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T172378 NZ_CP079742:4235800-4237110 [Aeromonas rivuli]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGGGTCATGGTTAGCACAACCAGGCAGCCGTCCCATCTCACTCTCCATGCCATTGCGCCATCAGCCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCCCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCGGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTGCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGTCTACA
CCCACGCGATGCAAAGCTGGCGATGGGCCTGACCGCGACTAAGGGCAAGAAATATGCGATAGAGCAGATATTTCCTCGCC
ATTTCTATCAGACTGCCAAAGCGGTTGGATTTGAAAGGGTTCAAATGGAAGTGATCCTAAACGAAATGGCCAGTAGTCTG
GATGAAGTGATCTCGGCCGTCCGTCAGCAGTTACCAGATACATTTCCCGCCCAGATTGCGGACTCGATTCTGGATGGGCT
CAGCACCAGAGCGCAGCGTTTAACTCTGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT172378 NZ_CP061337:588633-588690 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin