Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 284386..285098 Replicon chromosome
Accession NZ_CP061321
Organism Polynucleobacter sp. MWH-UH2A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IC571_RS01545 Protein ID WP_215317058.1
Coordinates 284802..285098 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IC571_RS01540 Protein ID WP_215317055.1
Coordinates 284386..284796 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC571_RS01510 (IC571_01510) 279657..280427 - 771 WP_215317043.1 3-deoxy-manno-octulosonate cytidylyltransferase -
IC571_RS01515 (IC571_01515) 280438..280617 - 180 WP_215317045.1 Trm112 family protein -
IC571_RS01520 (IC571_01520) 280655..281740 - 1086 WP_215317047.1 tetraacyldisaccharide 4'-kinase -
IC571_RS01525 (IC571_01525) 281763..282209 - 447 WP_215317049.1 biopolymer transporter ExbD -
IC571_RS01530 (IC571_01530) 282206..282841 - 636 WP_215317051.1 MotA/TolQ/ExbB proton channel family protein -
IC571_RS01535 (IC571_01535) 283165..284379 + 1215 WP_215317053.1 exodeoxyribonuclease VII large subunit -
IC571_RS01540 (IC571_01540) 284386..284796 - 411 WP_215317055.1 transcriptional regulator Antitoxin
IC571_RS01545 (IC571_01545) 284802..285098 - 297 WP_215317058.1 type II toxin-antitoxin system HigB family toxin Toxin
IC571_RS01550 (IC571_01550) 285158..286195 - 1038 WP_215317060.1 UDP-N-acetylmuramate dehydrogenase -
IC571_RS01555 (IC571_01555) 286275..286760 + 486 WP_215317062.1 YajQ family cyclic di-GMP-binding protein -
IC571_RS01560 (IC571_01560) 286753..287676 + 924 WP_215317064.1 site-specific tyrosine recombinase XerD -
IC571_RS01565 (IC571_01565) 287731..288363 + 633 WP_215317066.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
IC571_RS01570 (IC571_01570) 288436..288807 + 372 WP_215317068.1 MAPEG family protein -
IC571_RS01575 (IC571_01575) 288822..289589 + 768 WP_215317070.1 GTP cyclohydrolase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(27-96)

Antitoxin

Antitoxin HigA

(11-134)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11836.70 Da        Isoelectric Point: 9.6265

>T172349 WP_215317058.1 NZ_CP061321:c285098-284802 [Polynucleobacter sp. MWH-UH2A]
MQYNPQIKVITNRRLLDFPERYKDAFEPLQSWRKLIEFGSYKNFAELKQVFRSADKVGDLFVFNICGNKYRLITFLQFER
QLCYIKAVLTHKEYDKDG

Download         Length: 297 bp

>T172349 NZ_CP079735:3907728-3907985 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15540.02 Da        Isoelectric Point: 9.8399

>AT172349 WP_215317055.1 NZ_CP061321:c284796-284386 [Polynucleobacter sp. MWH-UH2A]
MNLNDLKKAWENLSKTVNLSPIRTEKQYKKMVQLADMLSDVIASSKKHSLLDLFELVSELIRAYEHEHFPVKDAKPQDIL
AFLMQEHHLKQSDLPEVGNQSVISQILAGARQLNVRQINALAKRFKVSAGVFFERA

Download         Length: 411 bp

>AT172349 NZ_CP079735:3907997-3908542 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References