Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 676166..676785 Replicon chromosome
Accession NZ_CP061316
Organism Polynucleobacter sp. AP-Jannik-300A-C4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FD975_RS03535 Protein ID WP_215303164.1
Coordinates 676166..676489 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FD975_RS03540 Protein ID WP_215303166.1
Coordinates 676486..676785 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD975_RS03510 (FD975_03510) 672666..673424 + 759 WP_215303157.1 molybdate ABC transporter substrate-binding protein -
FD975_RS03515 (FD975_03515) 673462..673788 + 327 WP_215303158.1 metalloregulator ArsR/SmtB family transcription factor -
FD975_RS03520 (FD975_03520) 673788..674267 + 480 WP_215303160.1 arsenate reductase ArsC -
FD975_RS03525 (FD975_03525) 674264..675316 + 1053 WP_215303162.1 ACR3 family arsenite efflux transporter -
FD975_RS03530 (FD975_03530) 675317..676036 + 720 WP_256443840.1 arsenical resistance protein ArsH -
FD975_RS03535 (FD975_03535) 676166..676489 + 324 WP_215303164.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FD975_RS03540 (FD975_03540) 676486..676785 + 300 WP_215303166.1 helix-turn-helix transcriptional regulator Antitoxin
FD975_RS03545 (FD975_03545) 676812..677048 - 237 WP_215303168.1 hypothetical protein -
FD975_RS03550 (FD975_03550) 677119..677544 - 426 WP_215303169.1 universal stress protein -
FD975_RS03555 (FD975_03555) 677664..678437 - 774 WP_215303171.1 TSUP family transporter -
FD975_RS03560 (FD975_03560) 678553..679446 + 894 WP_215303173.1 pseudouridine synthase -
FD975_RS03565 (FD975_03565) 679597..680226 + 630 WP_215303175.1 nuclease-related domain-containing protein -
FD975_RS03570 (FD975_03570) 680332..680841 + 510 WP_215303176.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-95)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12473.74 Da        Isoelectric Point: 9.7310

>T172340 WP_215303164.1 NZ_CP061316:676166-676489 [Polynucleobacter sp. AP-Jannik-300A-C4]
MTYTIRYYSPDVLEQIFDLPISLQARYIALTQRMIEYGPHLGLPHTDSFGGGLFELRLKGIEGIARVFFCTVVEREIVML
HSFIKKSQKTPDKELRLAKLRMREVKL

Download         Length: 324 bp

>T172340 NZ_CP079735:2236319-2236606 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10745.64 Da        Isoelectric Point: 10.9409

>AT172340 WP_215303166.1 NZ_CP061316:676486-676785 [Polynucleobacter sp. AP-Jannik-300A-C4]
MKTKTLTHKQAVGKMLKNPAVKAEVERLNKEEFAILDEILQARKAAGLSQAEVARRMGTQAPAIARLESSLATGKHSPSL
STLRKYAAALGKKVELHLV

Download         Length: 300 bp

>AT172340 NZ_CP079735:2236080-2236319 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References