Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1158729..1159350 Replicon chromosome
Accession NZ_CP061312
Organism Polynucleobacter sp. AP-Sving-400A-A2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C2758_RS06095 Protein ID WP_251369144.1
Coordinates 1158729..1159043 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C2758_RS06100 Protein ID WP_215327395.1
Coordinates 1159036..1159350 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2758_RS10745 1154606..1154743 - 138 WP_251369142.1 DUF86 domain-containing protein -
C2758_RS10750 1154737..1154961 - 225 WP_251369143.1 DUF86 domain-containing protein -
C2758_RS06065 (C2758_06065) 1154958..1155248 - 291 WP_215327390.1 nucleotidyltransferase domain-containing protein -
C2758_RS06070 (C2758_06070) 1155245..1155472 - 228 WP_215327391.1 hypothetical protein -
C2758_RS06075 (C2758_06075) 1155621..1156235 - 615 WP_215327392.1 recombination mediator RecR -
C2758_RS06080 (C2758_06080) 1156261..1156584 - 324 WP_215327393.1 YbaB/EbfC family nucleoid-associated protein -
C2758_RS06085 (C2758_06085) 1156612..1158279 - 1668 WP_215327394.1 DNA polymerase III subunit gamma/tau -
C2758_RS06095 (C2758_06095) 1158729..1159043 + 315 WP_251369144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2758_RS06100 (C2758_06100) 1159036..1159350 + 315 WP_215327395.1 helix-turn-helix transcriptional regulator Antitoxin
C2758_RS06105 (C2758_06105) 1159352..1159522 - 171 WP_215327396.1 hypothetical protein -
C2758_RS06110 (C2758_06110) 1159551..1159700 - 150 WP_215327397.1 hypothetical protein -
C2758_RS06115 (C2758_06115) 1159726..1160127 - 402 WP_215327398.1 hypothetical protein -
C2758_RS10785 1160213..1160344 - 132 WP_256441892.1 hypothetical protein -
C2758_RS06120 (C2758_06120) 1160989..1161162 + 174 WP_215327399.1 hypothetical protein -
C2758_RS06125 (C2758_06125) 1161174..1161608 + 435 WP_215327400.1 polymer-forming cytoskeletal protein -
C2758_RS06130 (C2758_06130) 1161658..1162056 + 399 WP_215327401.1 hypothetical protein -
C2758_RS06135 (C2758_06135) 1162076..1162603 - 528 WP_215330142.1 HD domain-containing protein -
C2758_RS06140 (C2758_06140) 1162763..1163740 - 978 WP_215327402.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-96)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12071.19 Da        Isoelectric Point: 10.2162

>T172329 WP_251369144.1 NZ_CP061312:1158729-1159043 [Polynucleobacter sp. AP-Sving-400A-A2]
MYFNERTKVEILAWPAGILADYRRLLDLMEQHGADLRLPHSRSMGDGLFEIRCKGSEGIGRVFYGMMIGKQIIILHSFIK
KTQETPDKEIKKARKRLKEVKEHG

Download         Length: 315 bp

>T172329 NZ_CP079735:c610348-609884 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11724.41 Da        Isoelectric Point: 9.5772

>AT172329 WP_215327395.1 NZ_CP061312:1159036-1159350 [Polynucleobacter sp. AP-Sving-400A-A2]
MVKHKDTFSPVPHTHKDDQKLFANPEFKRAWDALEEEYAALSELFQARKEAGLTQEQVAVIMGTTKSAISRLESSIRSDS
HSPSFSTLRKYANACGKKLLIKMV

Download         Length: 315 bp

>AT172329 NZ_CP079735:c610683-610348 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References