Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 333378..333969 Replicon chromosome
Accession NZ_CP061298
Organism Polynucleobacter paludilacus strain MWH-Mekk-C3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AOC06_RS01855 Protein ID WP_112203122.1
Coordinates 333378..333656 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AOC06_RS01860 Protein ID WP_215272412.1
Coordinates 333664..333969 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC06_RS01830 (AOC06_01830) 328720..329739 - 1020 WP_112294897.1 ionic transporter y4hA -
AOC06_RS01835 (AOC06_01835) 329810..330172 + 363 WP_215284471.1 CbiX/SirB N-terminal domain-containing protein -
AOC06_RS01840 (AOC06_01840) 330095..330907 - 813 WP_215284657.1 uroporphyrinogen-III C-methyltransferase -
AOC06_RS01845 (AOC06_01845) 330919..331509 - 591 WP_215366349.1 DUF934 domain-containing protein -
AOC06_RS01850 (AOC06_01850) 331506..333206 - 1701 WP_215380767.1 nitrite/sulfite reductase -
AOC06_RS01855 (AOC06_01855) 333378..333656 + 279 WP_112203122.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOC06_RS01860 (AOC06_01860) 333664..333969 + 306 WP_215272412.1 HigA family addiction module antitoxin Antitoxin
AOC06_RS01865 (AOC06_01865) 334020..334268 + 249 WP_112203124.1 prevent-host-death family protein -
AOC06_RS01870 (AOC06_01870) 334352..334711 - 360 WP_112294892.1 hypothetical protein -
AOC06_RS01875 (AOC06_01875) 334725..334946 - 222 WP_215380769.1 hypothetical protein -
AOC06_RS01880 (AOC06_01880) 335129..335722 + 594 WP_112203130.1 DUF308 domain-containing protein -
AOC06_RS01885 (AOC06_01885) 335765..335935 + 171 WP_158525168.1 hypothetical protein -
AOC06_RS01890 (AOC06_01890) 336027..337094 + 1068 WP_112294891.1 acyltransferase -
AOC06_RS01895 (AOC06_01895) 337099..337626 - 528 WP_112208855.1 ribosome biogenesis factor YjgA -
AOC06_RS01900 (AOC06_01900) 337643..337954 - 312 WP_255880001.1 helix-turn-helix domain-containing protein -
AOC06_RS01905 (AOC06_01905) 337981..338298 - 318 WP_215380772.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10686.35 Da        Isoelectric Point: 10.1614

>T172315 WP_112203122.1 NZ_CP061298:333378-333656 [Polynucleobacter paludilacus]
MIHSFLCGLTKDLFDSKPSKKFGNIERAARRKLLQLHAATAISDLRTPPGNMLELLIGNRRGQYSIRINHQWRICFVWRE
DGAHNVEIVDYH

Download         Length: 279 bp

>T172315 NZ_CP079725:1985825-1985927 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11701.62 Da        Isoelectric Point: 5.7251

>AT172315 WP_215272412.1 NZ_CP061298:333664-333969 [Polynucleobacter paludilacus]
MTTKLLDEIHPGEILLEDFMKPMGITSRQLAADIDVSPSRISEIIHGTRPITADTALRLGLFFSMEPRFWLNLQSEYDMR
MAKRNLQEEIEPRIRVFRIAA

Download         Length: 306 bp

>AT172315 NZ_CP079725:c1985934-1985789 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References