Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 333378..333969 Replicon chromosome
Accession NZ_CP061298
Organism Polynucleobacter paludilacus strain MWH-Mekk-C3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AOC06_RS01855 Protein ID WP_112203122.1
Coordinates 333378..333656 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AOC06_RS01860 Protein ID WP_215272412.1
Coordinates 333664..333969 (+) Length 102 a.a.

Genomic Context

AOC06_RS01835AOC06_RS01855AOC06_RS01860AOC06_RS01865AOC06_RS01880AOC06_RS01885AOC06_RS01890AOC06_RS01830AOC06_RS01840AOC06_RS01845AOC06_RS01850AOC06_RS01870AOC06_RS01875AOC06_RS01895AOC06_RS01900AOC06_RS01905
Location: 329810..330172 (363 bp)
Type: Others
Protein ID: WP_215284471.1
Location: 333378..333656 (279 bp)
Type: Toxin
Protein ID: WP_112203122.1
Location: 333664..333969 (306 bp)
Type: Antitoxin
Protein ID: WP_215272412.1
Location: 334020..334268 (249 bp)
Type: Others
Protein ID: WP_112203124.1
Location: 335129..335722 (594 bp)
Type: Others
Protein ID: WP_112203130.1
Location: 335765..335935 (171 bp)
Type: Others
Protein ID: WP_158525168.1
Location: 336027..337094 (1068 bp)
Type: Others
Protein ID: WP_112294891.1
Location: 328720..329739 (1020 bp)
Type: Others
Protein ID: WP_112294897.1
Location: 330095..330907 (813 bp)
Type: Others
Protein ID: WP_215284657.1
Location: 330919..331509 (591 bp)
Type: Others
Protein ID: WP_215366349.1
Location: 331506..333206 (1701 bp)
Type: Others
Protein ID: WP_215380767.1
Location: 334352..334711 (360 bp)
Type: Others
Protein ID: WP_112294892.1
Location: 334725..334946 (222 bp)
Type: Others
Protein ID: WP_215380769.1
Location: 337099..337626 (528 bp)
Type: Others
Protein ID: WP_112208855.1
Location: 337643..337954 (312 bp)
Type: Others
Protein ID: WP_255880001.1
Location: 337981..338298 (318 bp)
Type: Others
Protein ID: WP_215380772.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AOC06_RS01830 (AOC06_01830)328720..329739-1020WP_112294897.1ionic transporter y4hA-
AOC06_RS01835 (AOC06_01835)329810..330172+363WP_215284471.1CbiX/SirB N-terminal domain-containing protein-
AOC06_RS01840 (AOC06_01840)330095..330907-813WP_215284657.1uroporphyrinogen-III C-methyltransferase-
AOC06_RS01845 (AOC06_01845)330919..331509-591WP_215366349.1DUF934 domain-containing protein-
AOC06_RS01850 (AOC06_01850)331506..333206-1701WP_215380767.1nitrite/sulfite reductase-
AOC06_RS01855 (AOC06_01855)333378..333656+279WP_112203122.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AOC06_RS01860 (AOC06_01860)333664..333969+306WP_215272412.1HigA family addiction module antitoxinAntitoxin
AOC06_RS01865 (AOC06_01865)334020..334268+249WP_112203124.1prevent-host-death family protein-
AOC06_RS01870 (AOC06_01870)334352..334711-360WP_112294892.1hypothetical protein-
AOC06_RS01875 (AOC06_01875)334725..334946-222WP_215380769.1hypothetical protein-
AOC06_RS01880 (AOC06_01880)335129..335722+594WP_112203130.1DUF308 domain-containing protein-
AOC06_RS01885 (AOC06_01885)335765..335935+171WP_158525168.1hypothetical protein-
AOC06_RS01890 (AOC06_01890)336027..337094+1068WP_112294891.1acyltransferase-
AOC06_RS01895 (AOC06_01895)337099..337626-528WP_112208855.1ribosome biogenesis factor YjgA-
AOC06_RS01900 (AOC06_01900)337643..337954-312WP_255880001.1helix-turn-helix domain-containing protein-
AOC06_RS01905 (AOC06_01905)337981..338298-318WP_215380772.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10686.35 Da        Isoelectric Point: 10.1614

>T172315 WP_112203122.1 NZ_CP061298:333378-333656 [Polynucleobacter paludilacus]
MIHSFLCGLTKDLFDSKPSKKFGNIERAARRKLLQLHAATAISDLRTPPGNMLELLIGNRRGQYSIRINHQWRICFVWRE
DGAHNVEIVDYH

Download         Length: 279 bp

>T172315 NZ_CP079725:1985825-1985927 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11701.62 Da        Isoelectric Point: 5.7251

>AT172315 WP_215272412.1 NZ_CP061298:333664-333969 [Polynucleobacter paludilacus]
MTTKLLDEIHPGEILLEDFMKPMGITSRQLAADIDVSPSRISEIIHGTRPITADTALRLGLFFSMEPRFWLNLQSEYDMR
MAKRNLQEEIEPRIRVFRIAA

Download         Length: 306 bp

>AT172315 NZ_CP079725:c1985934-1985789 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References