Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2008571..2009202 Replicon chromosome
Accession NZ_CP061295
Organism Polynucleobacter sp. MWH-S4W17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C2755_RS10110 Protein ID WP_072582000.1
Coordinates 2008571..2008894 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C2755_RS10115 Protein ID WP_072582115.1
Coordinates 2008915..2009202 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2755_RS10080 (C2755_10080) 2004207..2004596 + 390 WP_215321196.1 hypothetical protein -
C2755_RS10085 (C2755_10085) 2004760..2004969 - 210 WP_215321197.1 BrnA antitoxin family protein -
C2755_RS10090 (C2755_10090) 2004981..2005259 - 279 WP_215321198.1 BrnT family toxin -
C2755_RS10095 (C2755_10095) 2005419..2006315 - 897 WP_215321199.1 LysR family transcriptional regulator -
C2755_RS10100 (C2755_10100) 2006399..2007358 + 960 WP_215281181.1 sodium-dependent bicarbonate transport family permease -
C2755_RS10105 (C2755_10105) 2007374..2008228 + 855 WP_215321200.1 hypothetical protein -
C2755_RS10110 (C2755_10110) 2008571..2008894 + 324 WP_072582000.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2755_RS10115 (C2755_10115) 2008915..2009202 + 288 WP_072582115.1 helix-turn-helix transcriptional regulator Antitoxin
C2755_RS10120 (C2755_10120) 2009306..2009653 + 348 WP_072582001.1 DUF3024 domain-containing protein -
C2755_RS10125 (C2755_10125) 2009835..2010344 - 510 WP_215321201.1 hypothetical protein -
C2755_RS10130 (C2755_10130) 2010406..2010771 - 366 WP_215321202.1 hypothetical protein -
C2755_RS10135 (C2755_10135) 2011002..2011931 + 930 WP_215321203.1 carbohydrate porin -
C2755_RS10140 (C2755_10140) 2011939..2012331 + 393 WP_251368576.1 carbohydrate porin -
C2755_RS10145 (C2755_10145) 2012479..2012877 - 399 WP_215321204.1 DUF1398 family protein -
C2755_RS10150 (C2755_10150) 2013009..2013971 - 963 WP_215321205.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-89)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12352.50 Da        Isoelectric Point: 9.4149

>T172307 WP_072582000.1 NZ_CP061295:2008571-2008894 [Polynucleobacter sp. MWH-S4W17]
MSYSILYYSEQVQEDIMNLPDTLQARYIGLTTRMIEHGPNLGLPHTDSFGGGLFELRLKGAEGIARVFFCTMVEKEIVML
HSFIKKTQKTPEKELKIAKARMKEWKK

Download         Length: 324 bp

>T172307 NZ_CP079718:c3748117-3747677 [Shewanella xiamenensis]
GTGGCCGAGCTGCGCCATAGTTTTAGTGTAAAAGCCTCCTTTGACCAACGTCTCTCGTTGGTCGTATTTGTTTGTGTCTG
TAGCACTTCTTTACTTCTCTGGCCAGAAACGGATACCGCAGTACTACATGGACTGAGGGCTATATTCGCCGTCTTAATAT
TGGGATTCTTGTGCTCTCAGTTATGGCAACTGAGGAAATGGCATTGCCGTTTTGAGCTTAATGGTCAAGGAGAAGGCTGG
CTATCAACGGGAGAGGCGTTTCACGTATTGCAAAGAACTTGGGTAACGCCGTTTATCTGCTTGGTTTACTATCAATCTGC
AAATAAGTTGCATCTCTTACCTCTATGGGCGGATATGTTTAATGATACAGATTATCGCCACTTGTGCCGACTATTACTTA
AAGTTAAAACTCAGGCGGTGAGCCAACACGAACCAATTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10380.35 Da        Isoelectric Point: 10.9446

>AT172307 WP_072582115.1 NZ_CP061295:2008915-2009202 [Polynucleobacter sp. MWH-S4W17]
MLTHKQMISKMLKKPAVKAAVKELDRTEFAILDEILTARKEAGLTQAQVAKKMGTQTPAIARLESSLATGKHSPSLTTLR
KYAAALGKRVELHLV

Download         Length: 288 bp

>AT172307 NZ_CP079718:c3748346-3748098 [Shewanella xiamenensis]
TTGGAGTTAATGAACATTGCACGGGTCCGTTGGGCATGTCGCCGCGGAATGCTCGAATTAGACGTTTTGTTCCAGCCCTT
CGTTGAGAATGTTTATCAGGATTTGTCTGATGAAGATAAAGCCCTGTTTATTCGTTTGCTCGAGTGTGAAGATCCTGAAT
TATTTGCATGGTTTATGGGTCATGAAGTTTGCCCTGATCCTGAGCTTGCCCGCATGGTAGTGCAAGTCCGTGGCCGAGCT
GCGCCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References