Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 376951..377561 Replicon chromosome
Accession NZ_CP061292
Organism Polynucleobacter sp. MWH-UH24A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ICV32_RS01980 Protein ID WP_215371493.1
Coordinates 376951..377229 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ICV32_RS01985 Protein ID WP_215371496.1
Coordinates 377250..377561 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICV32_RS01970 (ICV32_01965) 372344..375934 + 3591 WP_215371490.1 DNA polymerase III subunit alpha -
ICV32_RS01975 (ICV32_01970) 375938..376810 - 873 WP_215371492.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
ICV32_RS01980 (ICV32_01975) 376951..377229 + 279 WP_215371493.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ICV32_RS01985 (ICV32_01980) 377250..377561 + 312 WP_215371496.1 HigA family addiction module antitoxin Antitoxin
ICV32_RS01990 (ICV32_01985) 377575..380475 - 2901 WP_215371497.1 valine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10755.30 Da        Isoelectric Point: 10.0938

>T172294 WP_215371493.1 NZ_CP061292:376951-377229 [Polynucleobacter sp. MWH-UH24A]
MIIQFKHRGLQLFFTKGSYKGIPVQFASRIERILDRLDSSMSPNDMNLPGYRFHELKGRRKGVYAVSVSGNWRISFEFKD
SDVVNVNLEDYH

Download         Length: 279 bp

>T172294 NZ_CP079715:c2586410-2586234 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11292.15 Da        Isoelectric Point: 10.3485

>AT172294 WP_215371496.1 NZ_CP061292:377250-377561 [Polynucleobacter sp. MWH-UH24A]
MRNPSRRPTHPGAVLREDILPSLGISQAALAEYLGVSRLTVSEILLEKRAVSAEMAMRISKAIGGSPESWLQMQSAVDLW
DVAQRFKQDPAKLPKPIPNLAFA

Download         Length: 312 bp

>AT172294 NZ_CP079715:2586111-2586166 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References