Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1221139..1221649 Replicon chromosome
Accession NZ_CP061285
Organism Polynucleobacter sp. MWH-UH35A

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ICV36_RS06365 Protein ID WP_215399860.1
Coordinates 1221139..1221402 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag ICV36_RS06370 Protein ID WP_215401590.1
Coordinates 1221392..1221649 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICV36_RS06345 (ICV36_06340) 1216604..1217581 - 978 WP_215399854.1 hydroxymethylbilane synthase -
ICV36_RS06350 (ICV36_06345) 1217625..1219043 + 1419 WP_215399856.1 argininosuccinate lyase -
ICV36_RS06355 (ICV36_06350) 1219049..1219600 + 552 WP_215399858.1 TRAP transporter small permease subunit -
ICV36_RS06360 (ICV36_06355) 1219597..1221126 + 1530 WP_215399859.1 TRAP transporter large permease subunit -
ICV36_RS06365 (ICV36_06360) 1221139..1221402 - 264 WP_215399860.1 Txe/YoeB family addiction module toxin Toxin
ICV36_RS06370 (ICV36_06365) 1221392..1221649 - 258 WP_215401590.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ICV36_RS06375 (ICV36_06370) 1221759..1224026 - 2268 WP_215399862.1 arginine/lysine/ornithine decarboxylase -
ICV36_RS06380 (ICV36_06375) 1224023..1224937 - 915 WP_215399863.1 ion channel -
ICV36_RS06385 (ICV36_06380) 1224950..1225516 - 567 WP_071464932.1 dCTP deaminase -
ICV36_RS06390 (ICV36_06385) 1225557..1226399 - 843 WP_215399865.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10339.79 Da        Isoelectric Point: 8.8692

>T172280 WP_215399860.1 NZ_CP061285:c1221402-1221139 [Polynucleobacter sp. MWH-UH35A]
MLSRLVWTNAAWSDYVYWQGQDKKTLKRINSLIKDALRNPQDGIGKPEELRESLSGFWSRRIDDAHRLVYAIEKDQLVII
ACRYHYE

Download         Length: 264 bp

>T172280 NZ_CP061285:c1221402-1221139 [Polynucleobacter sp. MWH-UH35A]
ATGCTAAGTAGGCTGGTGTGGACAAATGCAGCATGGTCTGACTATGTGTATTGGCAGGGGCAGGACAAAAAAACCTTAAA
GCGTATTAACTCTTTAATTAAAGATGCCTTAAGAAATCCACAGGATGGTATTGGGAAACCAGAGGAGCTTAGGGAGAGTC
TGTCAGGATTTTGGTCAAGAAGAATCGATGATGCACATCGGCTAGTGTATGCAATTGAAAAAGACCAGCTTGTAATAATT
GCTTGTCGATATCACTATGAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9614.16 Da        Isoelectric Point: 9.6569

>AT172280 WP_215401590.1 NZ_CP061285:c1221649-1221392 [Polynucleobacter sp. MWH-UH35A]
MRIINFSDARNQFKQVIDQVVADCDIAVISRRDAEDAVVMSLNTYNSMMETLHLLKSPANVKHLEKSLAQYRKGHIKAKA
LVDAK

Download         Length: 258 bp

>AT172280 NZ_CP061285:c1221649-1221392 [Polynucleobacter sp. MWH-UH35A]
ATGAGGATCATTAATTTTTCTGACGCAAGAAATCAATTTAAGCAAGTAATTGATCAGGTAGTGGCAGATTGTGACATTGC
TGTTATCTCGCGCAGAGATGCAGAAGATGCTGTAGTGATGTCTTTGAATACCTATAACAGCATGATGGAAACACTCCACT
TATTAAAATCTCCCGCTAACGTTAAACATCTGGAGAAATCTTTGGCGCAATATCGCAAAGGGCACATCAAAGCAAAGGCC
TTGGTGGATGCTAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References