Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1574396..1574908 Replicon chromosome
Accession NZ_CP061208
Organism Streptococcus pneumoniae strain D39_P0

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag D39N_RS07755 Protein ID WP_000924721.1
Coordinates 1574396..1574650 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag D39N_RS07760 Protein ID WP_000388572.1
Coordinates 1574654..1574908 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D39N_RS07740 (D39N_01556) 1571497..1571811 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
D39N_RS07745 (D39N_01557) 1571836..1572462 - 627 WP_000775044.1 guanylate kinase -
D39N_RS07750 (D39N_01558) 1572592..1574205 - 1614 WP_000404940.1 ribonuclease Y -
D39N_RS07755 (D39N_01559) 1574396..1574650 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
D39N_RS07760 (D39N_01560) 1574654..1574908 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D39N_RS07765 (D39N_01561) 1575146..1576243 - 1098 WP_000156355.1 nucleotidyltransferase -
D39N_RS07770 (D39N_01562) 1576253..1576993 - 741 WP_000257069.1 class I SAM-dependent methyltransferase -
D39N_RS07775 (D39N_01563) 1577102..1577455 - 354 WP_001003001.1 ribosome silencing factor -
D39N_RS07780 (D39N_01564) 1577468..1577968 - 501 WP_000844717.1 cysteine hydrolase family protein -
D39N_RS07785 (D39N_01565) 1577969..1578562 - 594 WP_000121655.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
D39N_RS07790 (D39N_01566) 1578562..1579191 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
D39N_RS07795 (D39N_01567) 1579243..1579554 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T172268 WP_000924721.1 NZ_CP061208:c1574650-1574396 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T172268 NZ_CP079693:c14256-13906 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT172268 WP_000388572.1 NZ_CP061208:c1574908-1574654 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT172268 NZ_CP079693:c13901-13599 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References