Detailed information of TA system TA172231

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 1254793..1255205
• Replicon: chromosome
• Accession: NZ_CP061206
• Organism: Escherichia coli strain DA61218

Toxin (Protein)

• Gene name: symE
• Uniprot ID: Q8FA88
• Locus tag: ICI53_RS05905
• Protein ID: WP_000132630.1
• Coordinates: 1254864..1255205 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	1254793..1254869 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICI53_RS05895	1251405..1252874	+	1470	WP_001315223.1	type I restriction-modification system subunit M	-
ICI53_RS05900	1252874..1254643	+	1770	WP_000110076.1	restriction endonuclease subunit S	-
-	1254793..1254869	-	77	NuclAT_6	-	Antitoxin
-	1254793..1254869	-	77	NuclAT_6	-	Antitoxin
-	1254793..1254869	-	77	NuclAT_6	-	Antitoxin
-	1254793..1254869	-	77	NuclAT_6	-	Antitoxin
-	1254793..1254869	-	77	NuclAT_7	-	Antitoxin
-	1254793..1254869	-	77	NuclAT_7	-	Antitoxin
-	1254793..1254869	-	77	NuclAT_7	-	Antitoxin
-	1254793..1254869	-	77	NuclAT_7	-	Antitoxin
ICI53_RS05905	1254864..1255205	+	342	WP_000132630.1	endoribonuclease SymE	Toxin
ICI53_RS05910	1255252..1257345	-	2094	WP_000648234.1	DUF262 domain-containing protein	-
ICI53_RS05915	1257443..1257523	-	81	WP_020233658.1	hypothetical protein	-
ICI53_RS05920	1257751..1258671	-	921	WP_000181195.1	Rpn family recombination-promoting nuclease/putative transposase	-
ICI53_RS05925	1258856..1260136	+	1281	WP_001304526.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12294.13 Da
• Isoelectric Point: 8.4982

>T172231 WP_000132630.1 NZ_CP061206:1254864-1255205 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T172231 NZ_CP079668:c5365199-5364816 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT172231 NZ_CP061206:c1254869-1254793 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y5T0

Antitoxin