Detailed information of TA system TA172229

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1173590..1173848
• Replicon: chromosome
• Accession: NZ_CP061206
• Organism: Escherichia coli strain DA61218

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: ICI53_RS05515
• Protein ID: WP_001181672.1
• Coordinates: 1173639..1173848 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1173590..1173647 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICI53_RS05500	1169419..1170678	-	1260	WP_000494928.1	hypothetical protein	-
ICI53_RS05505	1170807..1172300	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
ICI53_RS05510	1172320..1173081	-	762	WP_001274832.1	hypothetical protein	-
-	1173590..1173647	-	58	-	-	Antitoxin
ICI53_RS05515	1173639..1173848	+	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
ICI53_RS05520	1173953..1175083	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
ICI53_RS05525	1175172..1177088	-	1917	WP_000516135.1	molecular chaperone DnaK	-
ICI53_RS05530	1177460..1177864	+	405	WP_000843687.1	DUF2541 family protein	-
ICI53_RS05535	1177890..1178603	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T172229 WP_001181672.1 NZ_CP061206:1173639-1173848 [Escherichia coli]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T172229 NZ_CP079668:c4896646-4896362 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT172229 NZ_CP061206:c1173647-1173590 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin