Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 59415..59951 Replicon plasmid ps12201A.p1
Accession NZ_CP061201
Organism Piscirickettsia salmonis strain Ps12201A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag ICC15_RS19580 Protein ID WP_016211910.1
Coordinates 59679..59951 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag ICC15_RS19575 Protein ID WP_032126795.1
Coordinates 59415..59675 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICC15_RS19540 55214..55540 - 327 WP_016212298.1 hypothetical protein -
ICC15_RS19545 55781..56257 + 477 WP_188322515.1 Clp protease ClpP -
ICC15_RS19550 56372..56665 + 294 WP_075275158.1 transposase -
ICC15_RS19555 56626..57303 + 678 Protein_82 IS3 family transposase -
ICC15_RS19560 57450..57752 + 303 WP_098082791.1 IS3 family transposase -
ICC15_RS19565 57761..58462 - 702 WP_188322516.1 IS6 family transposase -
ICC15_RS19570 58552..59142 - 591 WP_016211912.1 site-specific integrase -
ICC15_RS19575 59415..59675 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ICC15_RS19580 59679..59951 + 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
ICC15_RS19585 60277..61398 - 1122 WP_016211913.1 hypothetical protein -
ICC15_RS19590 61831..62229 + 399 WP_075273786.1 helix-turn-helix domain-containing protein -
ICC15_RS19595 62238..62795 - 558 WP_081377915.1 IS3 family transposase -
ICC15_RS19600 62940..63269 - 330 WP_081377914.1 IS3 family transposase -
ICC15_RS19605 63386..63679 - 294 WP_032126637.1 transposase -
ICC15_RS19610 63739..64341 + 603 Protein_93 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..129149 129149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T172221 WP_016211910.1 NZ_CP061201:59679-59951 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T172221 NZ_CP079658:8311-8616 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT172221 WP_032126795.1 NZ_CP061201:59415-59675 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT172221 NZ_CP079658:8091-8309 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References