Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 4626503..4626722 Replicon chromosome
Accession NZ_CP061185
Organism Escherichia coli strain LD67-1

Toxin (Protein)


Gene name ldrD Uniprot ID A0A829L523
Locus tag IB283_RS21820 Protein ID WP_000170738.1
Coordinates 4626503..4626610 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 4626659..4626722 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IB283_RS21790 4621532..4623103 + 1572 WP_001204946.1 cellulose biosynthesis protein BcsE -
IB283_RS21795 4623100..4623291 + 192 WP_061892928.1 cellulose biosynthesis protein BcsF -
IB283_RS21800 4623288..4624967 + 1680 WP_022646241.1 cellulose biosynthesis protein BcsG -
IB283_RS21805 4625053..4625160 - 108 WP_000170736.1 type I toxin-antitoxin system toxin Ldr family protein -
IB283_RS21810 4625537..4625644 - 108 WP_000170738.1 type I toxin-antitoxin system toxin Ldr family protein -
- 4625701..4625756 + 56 NuclAT_18 - -
- 4625701..4625756 + 56 NuclAT_18 - -
- 4625701..4625756 + 56 NuclAT_18 - -
- 4625701..4625756 + 56 NuclAT_18 - -
- 4625701..4625756 + 56 NuclAT_21 - -
- 4625701..4625756 + 56 NuclAT_21 - -
- 4625701..4625756 + 56 NuclAT_21 - -
- 4625701..4625756 + 56 NuclAT_21 - -
- 4625701..4625756 + 56 NuclAT_24 - -
- 4625701..4625756 + 56 NuclAT_24 - -
- 4625701..4625756 + 56 NuclAT_24 - -
- 4625701..4625756 + 56 NuclAT_24 - -
- 4625701..4625756 + 56 NuclAT_27 - -
- 4625701..4625756 + 56 NuclAT_27 - -
- 4625701..4625756 + 56 NuclAT_27 - -
- 4625701..4625756 + 56 NuclAT_27 - -
- 4625701..4625758 + 58 NuclAT_12 - -
- 4625701..4625758 + 58 NuclAT_12 - -
- 4625701..4625758 + 58 NuclAT_12 - -
- 4625701..4625758 + 58 NuclAT_12 - -
- 4625701..4625758 + 58 NuclAT_15 - -
- 4625701..4625758 + 58 NuclAT_15 - -
- 4625701..4625758 + 58 NuclAT_15 - -
- 4625701..4625758 + 58 NuclAT_15 - -
IB283_RS21815 4626021..4626128 - 108 WP_000170738.1 type I toxin-antitoxin system toxin Ldr family protein -
- 4626177..4626240 + 64 NuclAT_19 - -
- 4626177..4626240 + 64 NuclAT_19 - -
- 4626177..4626240 + 64 NuclAT_19 - -
- 4626177..4626240 + 64 NuclAT_19 - -
- 4626177..4626240 + 64 NuclAT_22 - -
- 4626177..4626240 + 64 NuclAT_22 - -
- 4626177..4626240 + 64 NuclAT_22 - -
- 4626177..4626240 + 64 NuclAT_22 - -
- 4626177..4626240 + 64 NuclAT_25 - -
- 4626177..4626240 + 64 NuclAT_25 - -
- 4626177..4626240 + 64 NuclAT_25 - -
- 4626177..4626240 + 64 NuclAT_25 - -
- 4626177..4626240 + 64 NuclAT_28 - -
- 4626177..4626240 + 64 NuclAT_28 - -
- 4626177..4626240 + 64 NuclAT_28 - -
- 4626177..4626240 + 64 NuclAT_28 - -
- 4626177..4626242 + 66 NuclAT_13 - -
- 4626177..4626242 + 66 NuclAT_13 - -
- 4626177..4626242 + 66 NuclAT_13 - -
- 4626177..4626242 + 66 NuclAT_13 - -
- 4626177..4626242 + 66 NuclAT_16 - -
- 4626177..4626242 + 66 NuclAT_16 - -
- 4626177..4626242 + 66 NuclAT_16 - -
- 4626177..4626242 + 66 NuclAT_16 - -
IB283_RS21820 4626503..4626610 - 108 WP_000170738.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 4626659..4626722 + 64 NuclAT_17 - Antitoxin
- 4626659..4626722 + 64 NuclAT_17 - Antitoxin
- 4626659..4626722 + 64 NuclAT_17 - Antitoxin
- 4626659..4626722 + 64 NuclAT_17 - Antitoxin
- 4626659..4626722 + 64 NuclAT_20 - Antitoxin
- 4626659..4626722 + 64 NuclAT_20 - Antitoxin
- 4626659..4626722 + 64 NuclAT_20 - Antitoxin
- 4626659..4626722 + 64 NuclAT_20 - Antitoxin
- 4626659..4626722 + 64 NuclAT_23 - Antitoxin
- 4626659..4626722 + 64 NuclAT_23 - Antitoxin
- 4626659..4626722 + 64 NuclAT_23 - Antitoxin
- 4626659..4626722 + 64 NuclAT_23 - Antitoxin
- 4626659..4626722 + 64 NuclAT_26 - Antitoxin
- 4626659..4626722 + 64 NuclAT_26 - Antitoxin
- 4626659..4626722 + 64 NuclAT_26 - Antitoxin
- 4626659..4626722 + 64 NuclAT_26 - Antitoxin
- 4626659..4626724 + 66 NuclAT_11 - -
- 4626659..4626724 + 66 NuclAT_11 - -
- 4626659..4626724 + 66 NuclAT_11 - -
- 4626659..4626724 + 66 NuclAT_11 - -
- 4626659..4626724 + 66 NuclAT_14 - -
- 4626659..4626724 + 66 NuclAT_14 - -
- 4626659..4626724 + 66 NuclAT_14 - -
- 4626659..4626724 + 66 NuclAT_14 - -
IB283_RS21825 4627086..4628357 + 1272 WP_022646242.1 amino acid permease -
IB283_RS21830 4628387..4629391 - 1005 WP_000107033.1 dipeptide ABC transporter ATP-binding subunit DppF -
IB283_RS21835 4629388..4630371 - 984 WP_001196481.1 dipeptide ABC transporter ATP-binding protein -
IB283_RS21840 4630382..4631284 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3864.67 Da        Isoelectric Point: 9.0157

>T172201 WP_000170738.1 NZ_CP061185:c4626610-4626503 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Download         Length: 108 bp

>T172201 NZ_CP079645:3352491-3353813 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 64 bp

>AT172201 NZ_CP061185:4626659-4626722 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L523

Antitoxin

Download structure file

References