Detailed information of TA system TA172177

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2003189..2003410
• Replicon: chromosome
• Accession: NZ_CP061185
• Organism: Escherichia coli strain LD67-1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A1D7PZ30
• Locus tag: IB283_RS09260
• Protein ID: WP_022645587.1
• Coordinates: 2003189..2003296 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2003344..2003410 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IB283_RS09235	1999033..2000115	+	1083	WP_022645584.1	peptide chain release factor 1	-
IB283_RS09240	2000115..2000948	+	834	WP_022645585.1	peptide chain release factor N(5)-glutamine methyltransferase	-
IB283_RS09245	2000945..2001337	+	393	WP_000200374.1	invasion regulator SirB2	-
IB283_RS09250	2001341..2002150	+	810	WP_088845989.1	invasion regulator SirB1	-
IB283_RS09255	2002186..2003040	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
IB283_RS09260	2003189..2003296	-	108	WP_022645587.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2003344..2003410	+	67	NuclAT_29	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_29	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_29	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_29	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_31	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_31	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_31	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_31	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_33	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_33	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_33	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_33	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_35	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_35	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_35	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_35	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_37	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_37	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_37	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_37	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_39	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_39	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_39	-	Antitoxin
-	2003344..2003410	+	67	NuclAT_39	-	Antitoxin
-	2003346..2003403	+	58	NuclAT_42	-	-
-	2003346..2003403	+	58	NuclAT_42	-	-
-	2003346..2003403	+	58	NuclAT_42	-	-
-	2003346..2003403	+	58	NuclAT_42	-	-
-	2003346..2003403	+	58	NuclAT_44	-	-
-	2003346..2003403	+	58	NuclAT_44	-	-
-	2003346..2003403	+	58	NuclAT_44	-	-
-	2003346..2003403	+	58	NuclAT_44	-	-
-	2003346..2003403	+	58	NuclAT_46	-	-
-	2003346..2003403	+	58	NuclAT_46	-	-
-	2003346..2003403	+	58	NuclAT_46	-	-
-	2003346..2003403	+	58	NuclAT_46	-	-
IB283_RS09265	2003493..2004859	-	1367	Protein_1800	IS3 family transposase	-
IB283_RS09270	2005168..2005275	-	108	WP_000170956.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	2005328..2005389	+	62	NuclAT_41	-	-
-	2005328..2005389	+	62	NuclAT_41	-	-
-	2005328..2005389	+	62	NuclAT_41	-	-
-	2005328..2005389	+	62	NuclAT_41	-	-
-	2005328..2005389	+	62	NuclAT_43	-	-
-	2005328..2005389	+	62	NuclAT_43	-	-
-	2005328..2005389	+	62	NuclAT_43	-	-
-	2005328..2005389	+	62	NuclAT_43	-	-
-	2005328..2005389	+	62	NuclAT_45	-	-
-	2005328..2005389	+	62	NuclAT_45	-	-
-	2005328..2005389	+	62	NuclAT_45	-	-
-	2005328..2005389	+	62	NuclAT_45	-	-
-	2005328..2005390	+	63	NuclAT_30	-	-
-	2005328..2005390	+	63	NuclAT_30	-	-
-	2005328..2005390	+	63	NuclAT_30	-	-
-	2005328..2005390	+	63	NuclAT_30	-	-
-	2005328..2005390	+	63	NuclAT_32	-	-
-	2005328..2005390	+	63	NuclAT_32	-	-
-	2005328..2005390	+	63	NuclAT_32	-	-
-	2005328..2005390	+	63	NuclAT_32	-	-
-	2005328..2005390	+	63	NuclAT_34	-	-
-	2005328..2005390	+	63	NuclAT_34	-	-
-	2005328..2005390	+	63	NuclAT_34	-	-
-	2005328..2005390	+	63	NuclAT_34	-	-
-	2005328..2005390	+	63	NuclAT_36	-	-
-	2005328..2005390	+	63	NuclAT_36	-	-
-	2005328..2005390	+	63	NuclAT_36	-	-
-	2005328..2005390	+	63	NuclAT_36	-	-
-	2005328..2005390	+	63	NuclAT_38	-	-
-	2005328..2005390	+	63	NuclAT_38	-	-
-	2005328..2005390	+	63	NuclAT_38	-	-
-	2005328..2005390	+	63	NuclAT_38	-	-
-	2005328..2005390	+	63	NuclAT_40	-	-
-	2005328..2005390	+	63	NuclAT_40	-	-
-	2005328..2005390	+	63	NuclAT_40	-	-
-	2005328..2005390	+	63	NuclAT_40	-	-
IB283_RS09275	2005681..2006781	-	1101	WP_001301956.1	sodium-potassium/proton antiporter ChaA	-
IB283_RS09280	2007051..2007281	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
IB283_RS09285	2007439..2008134	+	696	WP_012311798.1	glutathione-specific gamma-glutamylcyclotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4029.82 Da
• Isoelectric Point: 11.4779

>T172177 WP_022645587.1 NZ_CP061185:c2003296-2003189 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAVIVSWWRNRK

Nucleotide

• Length: 108 bp

>T172177 NZ_CP079636:c2758422-2757100 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT172177 NZ_CP061185:2003344-2003410 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGGGTTCTC

Structures

Toxin

• AlphaFold DB: A0A1D7PZ30

Antitoxin