Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3505246..3505754 Replicon chromosome
Accession NZ_CP061170
Organism Microbacterium sp. HY82

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HCR84_RS16930 Protein ID WP_166983207.1
Coordinates 3505494..3505754 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HCR84_RS16925 Protein ID WP_166983208.1
Coordinates 3505246..3505497 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCR84_RS16905 3500338..3501639 + 1302 WP_166983211.1 alpha-galactosidase -
HCR84_RS16910 3501818..3502978 + 1161 WP_166983297.1 MFS transporter -
HCR84_RS16915 3502975..3503574 + 600 WP_166983210.1 hypothetical protein -
HCR84_RS16920 3503755..3505131 + 1377 WP_166983209.1 MHS family MFS transporter -
HCR84_RS16925 3505246..3505497 + 252 WP_166983208.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HCR84_RS16930 3505494..3505754 + 261 WP_166983207.1 Txe/YoeB family addiction module toxin Toxin
HCR84_RS16935 3505862..3507172 + 1311 WP_166983206.1 GNAT family N-acetyltransferase -
HCR84_RS16940 3507240..3507647 - 408 WP_166983205.1 DUF3592 domain-containing protein -
HCR84_RS16945 3507666..3507944 - 279 WP_166983204.1 hypothetical protein -
HCR84_RS16950 3508086..3509495 + 1410 WP_166983203.1 aldehyde dehydrogenase family protein -
HCR84_RS16955 3509619..3510626 + 1008 WP_166983202.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10430.82 Da        Isoelectric Point: 9.6925

>T172164 WP_166983207.1 NZ_CP061170:3505494-3505754 [Microbacterium sp. HY82]
VRYVWDEDAWADYVWWQVQDRKVLKRINALLRDVARNGNEGIGKPEPLKHGFRGYWSRRITDEHRLVYKIVDDEVRVAAC
RYHYGR

Download         Length: 261 bp

>T172164 NZ_CP079632:32970-33386 [Klebsiella pneumoniae subsp. pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9564.61 Da        Isoelectric Point: 4.4663

>AT172164 WP_166983208.1 NZ_CP061170:3505246-3505497 [Microbacterium sp. HY82]
MRTMSYSESRANYAETLSKVVDDREEVVITRSGHEPVVIVSLDDYESLKETAYLLRNPENARRLMRSIERLDTGEGTERD
LAE

Download         Length: 252 bp

>AT172164 NZ_CP079632:32743-32973 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References