Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1275601..1276171 Replicon chromosome
Accession NZ_CP061170
Organism Microbacterium sp. HY82

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HCR84_RS06135 Protein ID WP_166984227.1
Coordinates 1275601..1275882 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HCR84_RS06140 Protein ID WP_166984226.1
Coordinates 1275869..1276171 (+) Length 101 a.a.

Genomic Context

HCR84_RS06115HCR84_RS06130HCR84_RS06135HCR84_RS06140HCR84_RS06145HCR84_RS06150HCR84_RS06170HCR84_RS06120HCR84_RS06125HCR84_RS06155HCR84_RS06160HCR84_RS06165
Location: 1271308..1272303 (996 bp)
Type: Others
Protein ID: WP_166984231.1
Location: 1274494..1275567 (1074 bp)
Type: Others
Protein ID: WP_166984228.1
Location: 1275601..1275882 (282 bp)
Type: Toxin
Protein ID: WP_166984227.1
Location: 1275869..1276171 (303 bp)
Type: Antitoxin
Protein ID: WP_166984226.1
Location: 1276177..1277007 (831 bp)
Type: Others
Protein ID: WP_166984225.1
Location: 1277145..1277582 (438 bp)
Type: Others
Protein ID: WP_166984224.1
Location: 1280239..1280781 (543 bp)
Type: Others
Protein ID: WP_166984220.1
Location: 1272376..1273677 (1302 bp)
Type: Others
Protein ID: WP_166984230.1
Location: 1273767..1274387 (621 bp)
Type: Others
Protein ID: WP_166984229.1
Location: 1277674..1278189 (516 bp)
Type: Others
Protein ID: WP_166984223.1
Location: 1278410..1279354 (945 bp)
Type: Others
Protein ID: WP_166984222.1
Location: 1279351..1279917 (567 bp)
Type: Others
Protein ID: WP_166984221.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HCR84_RS061151271308..1272303+996WP_166984231.1class II fructose-bisphosphatase-
HCR84_RS061201272376..1273677-1302WP_166984230.1DNA recombination protein RmuC-
HCR84_RS061251273767..1274387-621WP_166984229.1HAD hydrolase-like protein-
HCR84_RS061301274494..1275567+1074WP_166984228.1redox-regulated ATPase YchF-
HCR84_RS061351275601..1275882+282WP_166984227.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HCR84_RS061401275869..1276171+303WP_166984226.1HigA family addiction module antidote proteinAntitoxin
HCR84_RS061451276177..1277007+831WP_166984225.1ornithine carbamoyltransferase-
HCR84_RS061501277145..1277582+438WP_166984224.1VOC family protein-
HCR84_RS061551277674..1278189-516WP_166984223.1tetratricopeptide repeat protein-
HCR84_RS061601278410..1279354-945WP_166984222.1DMT family transporter-
HCR84_RS061651279351..1279917-567WP_166984221.1TetR/AcrR family transcriptional regulator-
HCR84_RS061701280239..1280781+543WP_166984220.1type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10782.26 Da        Isoelectric Point: 9.8481

>T172162 WP_166984227.1 NZ_CP061170:1275601-1275882 [Microbacterium sp. HY82]
VIRSFGSKDTERLWRRERVPSIDPRIHSVALRKLRQVGSAESLDDLRVPPGNRLEALKGNRAGQYSIRINDQWRICFVWT
VAGPEEVEIVDYH

Download         Length: 282 bp

>T172162 NZ_CP079630:58923-59405 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.70 Da        Isoelectric Point: 5.5882

>AT172162 WP_166984226.1 NZ_CP061170:1275869-1276171 [Microbacterium sp. HY82]
MTITDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRAITADTALRLGKYFGTSAQFWINLQAHYDL
DRAEDRVADQIAAITPLTVA

Download         Length: 303 bp

>AT172162 NZ_CP079630:58669-58935 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References