Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1828719..1829221 Replicon chromosome
Accession NZ_CP061101
Organism Escherichia coli strain 1EC213

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag IB009_RS08785 Protein ID WP_000767829.1
Coordinates 1828967..1829221 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag IB009_RS08780 Protein ID WP_001259255.1
Coordinates 1828719..1828970 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IB009_RS08755 1823896..1824963 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
IB009_RS08760 1824963..1826033 - 1071 WP_000108945.1 histidinol-phosphate transaminase -
IB009_RS08765 1826030..1827334 - 1305 WP_001446927.1 histidinol dehydrogenase -
IB009_RS08770 1827340..1828239 - 900 WP_032329340.1 ATP phosphoribosyltransferase -
IB009_RS08775 1828385..1828435 - 51 WP_001364200.1 his operon leader peptide -
IB009_RS08780 1828719..1828970 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IB009_RS08785 1828967..1829221 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IB009_RS08790 1829304..1830128 + 825 WP_000754749.1 SDR family oxidoreductase -
IB009_RS08795 1830174..1831103 + 930 WP_000803351.1 LysR family transcriptional regulator -
IB009_RS08800 1831318..1831380 + 63 WP_010723108.1 membrane protein YoeI -
IB009_RS08805 1831370..1832728 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IB009_RS08810 1832907..1833965 + 1059 WP_000492321.1 transport protein YeeE -
IB009_RS08815 1833979..1834206 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T172088 WP_000767829.1 NZ_CP061101:1828967-1829221 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T172088 NZ_CP079195:2878120-2878380 [Polaribacter sp. NJDZ03]
ATGAGATTAATTTGGTCAGCATCTTCTTGGAACGATTATGTCTATTGGCAAAAAGTTGATAAGAAAATTGTTAAAAGAAT
TAATGAACTTATTAAAAGTTGCGTTAGAACACCTTTTGAAGGGATTGGAAAACCAGAAGCTTTAAAAGGAGATTTACAAG
GGTATTGGTCTAGAAGAATAACATCTGAACATAGACTAGTATATAAATATGAGAATGAACAGCTATTAATTGCTGCTTGT
CGCTATCATTATGGGAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT172088 WP_001259255.1 NZ_CP061101:1828719-1828970 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT172088 NZ_CP079195:2877871-2878119 [Polaribacter sp. NJDZ03]
ATGGAAACAGTAAATTATACAGATTTTCGTTCCAATTTAAAACATTGGTTCGATAAGGTTTTTAATGATGTTAGTGATAT
CGTCATTAAAAGAAAAGGAGGAAAGGATTTAGTTCTAATTTCATTAGACGAATATAACTCTCTTAAGGAAACAAGTTATT
TGCTTACAGGGAAAAACAGAGATGTTTTATTAAATTCCATTAAAGAATTAGAAGCTGGCAAAGGATTTCAAAAAGAATTA
ATCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References