Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 610593..611183 Replicon chromosome
Accession NZ_CP061089
Organism Brucella sp. 6810

Toxin (Protein)


Gene name graT Uniprot ID A0A7L7MSL3
Locus tag IB024_RS14005 Protein ID WP_069714895.1
Coordinates 610593..610874 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A7L7MR57
Locus tag IB024_RS14010 Protein ID WP_008510700.1
Coordinates 610887..611183 (+) Length 99 a.a.

Genomic Context

IB024_RS13990IB024_RS13995IB024_RS14005IB024_RS14010IB024_RS14015IB024_RS14025IB024_RS14040IB024_RS14020IB024_RS14035
Location: 606172..607509 (1338 bp)
Type: Others
Protein ID: WP_187960517.1
Location: 607685..609874 (2190 bp)
Type: Others
Protein ID: WP_187960518.1
Location: 610593..610874 (282 bp)
Type: Toxin
Protein ID: WP_069714895.1
Location: 610887..611183 (297 bp)
Type: Antitoxin
Protein ID: WP_008510700.1
Location: 611433..611615 (183 bp)
Type: Others
Protein ID: WP_187960519.1
Location: 613312..614262 (951 bp)
Type: Others
Protein ID: WP_187960521.1
Location: 615740..616045 (306 bp)
Type: Others
Protein ID: WP_002971236.1
Location: 611748..612467 (720 bp)
Type: Others
Protein ID: WP_187960520.1
Location: 615222..615599 (378 bp)
Type: Others
Protein ID: WP_187960522.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IB024_RS13990606172..607509+1338WP_187960517.1DNA polymerase IV-
IB024_RS13995607685..609874+2190WP_187960518.1esterase-like activity of phytase family protein-
IB024_RS14005610593..610874+282WP_069714895.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IB024_RS14010610887..611183+297WP_008510700.1HigA family addiction module antidote proteinAntitoxin
IB024_RS14015611433..611615+183WP_187960519.1hypothetical protein-
IB024_RS14020611748..612467-720WP_187960520.1GGDEF domain-containing protein-
IB024_RS14025613312..614262+951WP_187960521.1IS481 family transposase-
IB024_RS14035615222..615599-378WP_187960522.1pyrimidine dimer DNA glycosylase/endonuclease V-
IB024_RS14040615740..616045+306WP_002971236.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10569.00 Da        Isoelectric Point: 8.0374

>T172079 WP_069714895.1 NZ_CP061089:610593-610874 [Brucella sp. 6810]
MIRSYKNSVTETVAWGKAPKGFPSDLVRVSVRKLTMLDNAVTLDDLRSPPGNRLEALKGDRQGQHSIRINDQWRICFVWT
DAGAEQVEIVDYH

Download         Length: 282 bp

>T172079 NZ_CP079188:c44093-43677 [Klebsiella pneumoniae subsp. pneumoniae]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11001.76 Da        Isoelectric Point: 5.6882

>AT172079 WP_008510700.1 NZ_CP061089:610887-611183 [Brucella sp. 6810]
MTNILPPVHPGEILREEYLIPLGMSAGALAKRLNVPRTRIERLATEQTNVTPDTALRLAKFLRTTPEFWMNMQASYDLKT
EAVAIQDQLAAIHEMEAA

Download         Length: 297 bp

>AT172079 NZ_CP079188:c44320-44090 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7L7MSL3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7L7MR57

References