Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 98064..98566 Replicon plasmid unnamed2
Accession NZ_CP061085
Organism Pantoea sp. MT58

Toxin (Protein)


Gene name yoeB Uniprot ID E0M3B6
Locus tag IAI47_RS21770 Protein ID WP_003850603.1
Coordinates 98312..98566 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E0M3B7
Locus tag IAI47_RS21765 Protein ID WP_003850602.1
Coordinates 98064..98315 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI47_RS21750 93877..94650 + 774 WP_003850595.1 (S)-acetoin forming diacetyl reductase -
IAI47_RS21755 94856..96307 + 1452 WP_071778552.1 flagellin -
IAI47_RS21760 96647..97960 + 1314 WP_008926802.1 CitMHS family transporter -
IAI47_RS21765 98064..98315 + 252 WP_003850602.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IAI47_RS21770 98312..98566 + 255 WP_003850603.1 Txe/YoeB family addiction module toxin Toxin
IAI47_RS21775 98684..101218 - 2535 WP_008926801.1 excinuclease ABC subunit UvrA -
IAI47_RS21780 101962..102186 + 225 WP_187961303.1 hypothetical protein -
IAI47_RS21785 102813..103259 + 447 WP_003850608.1 SgcJ/EcaC family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..131020 131020


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9912.31 Da        Isoelectric Point: 8.8485

>T172073 WP_003850603.1 NZ_CP061085:98312-98566 [Pantoea sp. MT58]
VKLTWSAEAWEDYLYWQDTDKKTVKKINELLKDASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVTEEALLIASC
RYHY

Download         Length: 255 bp

>T172073 NZ_CP079186:c2786107-2784785 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9323.52 Da        Isoelectric Point: 4.5702

>AT172073 WP_003850602.1 NZ_CP061085:98064-98315 [Pantoea sp. MT58]
MRAISYSEARQNLSATMVQTVEDKAPVLITRQNGESCVLMSLDEYNSLEETAYLLRSPKNARRLMDAIESLQSGKGTDRD
IIE

Download         Length: 252 bp

>AT172073 NZ_CP079186:c2786373-2786107 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCACTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0M3B6

Antitoxin

Source ID Structure
AlphaFold DB A0A501RXB0

References