Detailed information of TA system TA172026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 4349838..4350492
• Replicon: chromosome
• Accession: NZ_CP061079
• Organism: Pseudomonas chlororaphis strain qlu-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HLB40_RS19075
• Protein ID: WP_101284187.1
• Coordinates: 4349838..4350188 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HLB40_RS19080
• Protein ID: WP_009049793.1
• Coordinates: 4350178..4350492 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB40_RS19065	4346588..4348120	+	1533	WP_009049790.1	NADH-quinone oxidoreductase subunit M	-
HLB40_RS19070	4348128..4349591	+	1464	WP_009049791.1	NADH-quinone oxidoreductase subunit NuoN	-
HLB40_RS19075	4349838..4350188	+	351	WP_101284187.1	toxin	Toxin
HLB40_RS19080	4350178..4350492	+	315	WP_009049793.1	transcriptional regulator	Antitoxin
HLB40_RS19085	4350659..4352401	-	1743	WP_023964376.1	ABC transporter substrate-binding protein	-
HLB40_RS19090	4352565..4352837	-	273	WP_009049795.1	DUF2160 domain-containing protein	-
HLB40_RS19095	4352848..4353648	-	801	WP_007929618.1	carbohydrate ABC transporter permease	-
HLB40_RS19100	4353660..4354526	-	867	WP_009049796.1	sugar ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-100)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13812.81 Da
• Isoelectric Point: 8.5032

>T172026 WP_101284187.1 NZ_CP061079:4349838-4350188 [Pseudomonas chlororaphis]
MDALFIELPPFQRHRQDYLDDELFRSLQLELLKAPEAGDLIEGTDGLRKIRFVDERRHKGKRGGIRVIYYWWSGGAQLWL
FTLYAKNELNDLTPHQKKLLKQLLNREVEARTHHET

Nucleotide

• Length: 351 bp

>T172026 NZ_CP079155:2728262-2728546 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11917.85 Da
• Isoelectric Point: 10.6052

>AT172026 WP_009049793.1 NZ_CP061079:4350178-4350492 [Pseudomonas chlororaphis]
MKRDIFSELVEGFDALAKERQGKLTLRTYKVKLNALLPITAEEVLAVREQLNLSRSVFAMYLRTNTRTLENWEQGRAKPN
AQATTLIRLVQRFPDTVERLAALA

Nucleotide

• Length: 315 bp

>AT172026 NZ_CP079155:2728030-2728272 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA