Detailed information of TA system TA171968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1141..1658
• Replicon: plasmid pWS-25
• Accession: NZ_CP061043
• Organism: Staphylococcus warneri strain WS479

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IAR39_RS12505
• Protein ID: WP_187835432.1
• Coordinates: 1141..1407 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: IAR39_RS12510
• Protein ID: WP_187835433.1
• Coordinates: 1407..1658 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR39_RS12500	463..1008	+	546	WP_187835431.1	DUF536 domain-containing protein	-
IAR39_RS12505	1141..1407	-	267	WP_187835432.1	Txe/YoeB family addiction module toxin	Toxin
IAR39_RS12510	1407..1658	-	252	WP_187835433.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IAR39_RS12515	1807..2247	+	441	WP_187835434.1	hypothetical protein	-
IAR39_RS12520	2269..2412	+	144	Protein_5	AbrB family transcriptional regulator	-
IAR39_RS12525	2485..3306	-	822	WP_187835435.1	hypothetical protein	-
IAR39_RS12530	3510..3608	+	99	WP_187835436.1	type I toxin-antitoxin system Fst family toxin	-
IAR39_RS12535	4163..4537	+	375	WP_187835437.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..25160	25160

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10518.02 Da
• Isoelectric Point: 9.8724

>T171968 WP_187835432.1 NZ_CP061043:c1407-1141 [Staphylococcus warneri]
MAKLNITFSPQAFEDYEYFQQNDKKLVKKINDLLKSISRDGVLKGIGKPEKLRTNFSGYYSRRINHEHRLVYTVDDYHIK
IASCRYHY

Nucleotide

• Length: 267 bp

>T171968 NZ_CP079131:c132589-132305 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9455.57 Da
• Isoelectric Point: 4.3707

>AT171968 WP_187835433.1 NZ_CP061043:c1658-1407 [Staphylococcus warneri]
MLVKNYSNARQNLKALMTRVNDDSDVVTVTSTDNKNVVMMSESDYNSMMETLYLQQNPKNAEHIAQSIEDLERGNTITKE
IDV

Nucleotide

• Length: 252 bp

>AT171968 NZ_CP079131:c132821-132579 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA