Detailed information of TA system TA171966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1348409..1348919
• Replicon: chromosome
• Accession: NZ_CP061041
• Organism: Staphylococcus warneri strain WS479

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IAR39_RS06760
• Protein ID: WP_049416776.1
• Coordinates: 1348409..1348672 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: IAR39_RS06765
• Protein ID: WP_049416774.1
• Coordinates: 1348665..1348919 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR39_RS06745	1343857..1345227	-	1371	WP_049416781.1	citrate:proton symporter	-
IAR39_RS06750	1345532..1346641	-	1110	WP_050969455.1	NAD(P)-dependent alcohol dehydrogenase	-
IAR39_RS06755	1346803..1348251	+	1449	Protein_1292	aldehyde dehydrogenase family protein	-
IAR39_RS06760	1348409..1348672	-	264	WP_049416776.1	Txe/YoeB family addiction module toxin	Toxin
IAR39_RS06765	1348665..1348919	-	255	WP_049416774.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IAR39_RS06770	1349164..1351374	+	2211	WP_049416771.1	YSIRK-type signal peptide-containing protein	-
IAR39_RS06775	1351501..1351938	-	438	WP_002466379.1	hypothetical protein	-
IAR39_RS06780	1352089..1353411	-	1323	WP_049416769.1	PrsW family intramembrane metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10414.10 Da
• Isoelectric Point: 9.8163

>T171966 WP_049416776.1 NZ_CP061041:c1348672-1348409 [Staphylococcus warneri]
MSRLNILFTPDAFEDYKYWQIHDKKLLKKINHLIKCINRNGPLEGEGKPEALKGNFKGYYSRRINFEHRLVYKVHDSEII
IVSCKYQ

Nucleotide

• Length: 264 bp

>T171966 NZ_CP079129:c326-60 [Klebsiella pneumoniae subsp. pneumoniae]
TTGGTCTGGACGATTAACTATTCCGACCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGGATTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCATTCTGTGTGAGATCCGGGATGACGAGCTGGTTATCCTTGCCGCCACCATT
GGCCATCGCCGCGAAGTTTACGACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9373.33 Da
• Isoelectric Point: 4.0334

>AT171966 WP_049416774.1 NZ_CP061041:c1348919-1348665 [Staphylococcus warneri]
MAIVSYSIARKNFRSLIDKVNNDSDAVTITTNDSNAVLISESDYNAMMETLYLQQSPANAQHLAKSIEDVERGNTIEVDL
ESYE

Nucleotide

• Length: 255 bp

>AT171966 NZ_CP079129:c534-310 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
CTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAAGATTATTATCTTTCAGCAGAAACTGCCGCACGCGTTC
GCCGTGGTGATGAAGCCGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA