Detailed information of TA system TA171946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 844828..845404
• Replicon: chromosome
• Accession: NZ_CP061032
• Organism: Corynebacterium sp. zg-917

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: IAU68_RS04225
• Protein ID: WP_171193583.1
• Coordinates: 844828..845109 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: IAU68_RS04230
• Protein ID: WP_171193582.1
• Coordinates: 845096..845404 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAU68_RS04200	839933..840787	+	855	WP_016456425.1	23S ribosomal RNA methyltransferase Erm	-
IAU68_RS04205	842158..842508	-	351	WP_171193585.1	hypothetical protein	-
IAU68_RS04210	842505..843926	-	1422	WP_171193584.1	mercury(II) reductase	-
IAU68_RS04215	844025..844414	+	390	WP_070491030.1	heavy metal-responsive transcriptional regulator	-
IAU68_RS04220	844458..844706	-	249	Protein_819	LLM class flavin-dependent oxidoreductase	-
IAU68_RS04225	844828..845109	+	282	WP_171193583.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAU68_RS04230	845096..845404	+	309	WP_171193582.1	HigA family addiction module antidote protein	Antitoxin
IAU68_RS04235	845644..845901	-	258	WP_171193581.1	peptide chain release factor 1	-
IAU68_RS04240	845933..846238	-	306	Protein_823	putative glycolipid-binding domain-containing protein	-
IAU68_RS04245	846626..847054	-	429	WP_171193580.1	hypothetical protein	-
IAU68_RS04250	847243..847485	-	243	WP_171193659.1	hypothetical protein	-
IAU68_RS04255	847487..847732	-	246	WP_171193579.1	ribbon-helix-helix protein, CopG family	-
IAU68_RS04260	847833..848276	-	444	WP_171193578.1	aminoacyl-tRNA hydrolase	-
IAU68_RS04265	848298..848585	-	288	WP_171193577.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IAU68_RS04270	848595..848810	-	216	WP_171193576.1	ribbon-helix-helix protein, CopG family	-
IAU68_RS04275	848910..849273	+	364	Protein_830	VOC family protein	-
IAU68_RS04280	849302..850360	-	1059	WP_171193575.1	FUSC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	erm(X)	-	815684..852103	36419

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (5-98)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11065.48 Da
• Isoelectric Point: 9.1262

>T171946 WP_171193583.1 NZ_CP061032:844828-845109 [Corynebacterium sp. zg-917]
MIQSFADRDTERLWNRERVRSIDSRIHSVALRKLRQLGYAQTLDELRIPPGNRLEALNGDRRGQFSIRINDQWRICFRWS
AAGPEEVEIVDYH

Nucleotide

• Length: 282 bp

>T171946 NZ_CP079115:c4022843-4022526 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11331.23 Da
• Isoelectric Point: 6.8797

>AT171946 WP_171193582.1 NZ_CP061032:845096-845404 [Corynebacterium sp. zg-917]
MTTTDKLPPVHPGEILMEDFLKEMGITQHKLAVSIGVPPRRINEIVHGKRAVTADTALRLAKFFGMSPQFWLGLQTQYDL
DVAEGKILAEIERIQPVHAVSA

Nucleotide

• Length: 309 bp

>AT171946 NZ_CP079115:c4022533-4022246 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA