Detailed information of TA system TA171943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 947384..947955
• Replicon: chromosome
• Accession: NZ_CP061030
• Organism: Staphylococcus pseudintermedius strain Z0118SP0108

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IAU63_RS04610
• Protein ID: WP_187470716.1
• Coordinates: 947384..947698 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A3D8YKM0
• Locus tag: IAU63_RS04615
• Protein ID: WP_014612814.1
• Coordinates: 947698..947955 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAU63_RS12785	942724..943173	+	450	WP_206680132.1	hypothetical protein	-
IAU63_RS12790	944606..944707	-	102	Protein_871	KxYKxGKxW signal peptide domain-containing protein	-
IAU63_RS04600	945464..946957	+	1494	WP_014612817.1	malate dehydrogenase (quinone)	-
IAU63_RS04605	946971..947072	+	102	WP_019169745.1	DUF2648 domain-containing protein	-
IAU63_RS04610	947384..947698	-	315	WP_187470716.1	Txe/YoeB family addiction module toxin	Toxin
IAU63_RS04615	947698..947955	-	258	WP_014612814.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IAU63_RS04620	948149..950053	-	1905	WP_096533653.1	triacylglycerol lipase	-
IAU63_RS04625	950313..950807	+	495	WP_015729749.1	membrane protein	-
IAU63_RS04630	951101..951907	-	807	WP_187470717.1	arylamine N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-77)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12353.27 Da
• Isoelectric Point: 9.7293

>T171943 WP_187470716.1 NZ_CP061030:c947698-947384 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FLLGHIMSERYVNKCCESIDSELY

Nucleotide

• Length: 315 bp

>T171943 NZ_CP079115:791209-791619 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.87 Da
• Isoelectric Point: 4.1100

>AT171943 WP_014612814.1 NZ_CP061030:c947955-947698 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT171943 NZ_CP079115:790962-791228 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3D8YKM0