Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 440037..440709 Replicon chromosome
Accession NZ_CP061008
Organism Achromobacter xylosoxidans strain GD03

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IAG39_RS02080 Protein ID WP_118933430.1
Coordinates 440037..440402 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAG39_RS02085 Protein ID WP_059377351.1
Coordinates 440395..440709 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAG39_RS02050 435156..435950 + 795 WP_059377338.1 SDR family oxidoreductase -
IAG39_RS02055 435967..436788 + 822 WP_118933367.1 SDR family oxidoreductase -
IAG39_RS02060 436812..437324 + 513 WP_059377342.1 carboxymuconolactone decarboxylase family protein -
IAG39_RS02065 437369..438334 + 966 WP_059377344.1 tripartite tricarboxylate transporter substrate binding protein -
IAG39_RS02070 438410..439342 - 933 WP_187774074.1 c-type cytochrome -
IAG39_RS02080 440037..440402 + 366 WP_118933430.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IAG39_RS02085 440395..440709 + 315 WP_059377351.1 XRE family transcriptional regulator Antitoxin
IAG39_RS02090 440810..441565 - 756 WP_118933431.1 GntR family transcriptional regulator -
IAG39_RS02095 441562..443331 - 1770 WP_118933432.1 glycerol-3-phosphate dehydrogenase/oxidase -
IAG39_RS02100 443328..444818 - 1491 WP_118933433.1 carbohydrate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13828.48 Da        Isoelectric Point: 5.2376

>T171933 WP_118933430.1 NZ_CP061008:440037-440402 [Achromobacter xylosoxidans]
MAWEVEFTDEFEVWWNGLSEREQESVVATVGLLEARGTTLGFPHSSGINGSKHEHMRELRTQAGGRPLRTLYAFDPRRAA
ILLIGGDKTGNDRWYEEFVPLADKLYDDHLRLLRKEGQING

Download         Length: 366 bp

>T171933 NZ_CP079097:c3500357-3499860 [Methylococcus capsulatus]
TTGCCGCTTCTGGCTCCCCGACCGCTCGCTGAACATCATCGAACGGAAAGCTTCGCTTCCGGCATTACCTCCCTGGACGA
CTGGTTGAAGCGCAGAGCATTGGCCAATCAGTCCAGTGGCGCCTCCCGGACCTTCGTGGTCTGCGACGAACACCGGGTGA
TCGGGTATTACGCCCTCGCGGCCGCAGCGATCAGAATCCAGGACGCTTCGAGCCGGTTTCGGCGCAATATGCCCGATCCC
ATTCCCGTCGCGATTCTGGCGCGTCTCGCCGTGGATCAAGCTTACCAGGGTCAAGGGATTGGCCGCGCCCTATTCCGCGA
CGGCGCCCGACGTGTGGTTCAGGCCGCGGATACGCTTGGCATTCGTGGAATCGTCGTCCACGCCATTTCCGAGGACGCCA
AGGCGTTTTATCAAGCGCTGGGCTTTGATCCATCCCCGGTCGATGCCATGACACTCCTGGTGACGTTAAGCGACCTACGC
GCCGCACTGCCCGGCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11527.48 Da        Isoelectric Point: 10.4005

>AT171933 WP_059377351.1 NZ_CP061008:440395-440709 [Achromobacter xylosoxidans]
MAKKFGTLRAAMSPESQLRAKAATEQMLQEMPLQELRQARGLSQKVLAEVLHVQQPSIAKMEKRTDMYISTLRSHIEAMG
GKLEVVARFPDGAVKITNFSDLAA

Download         Length: 315 bp

>AT171933 NZ_CP079097:c3500645-3500361 [Methylococcus capsulatus]
ATGACCACGACTCACTCTCAGACCACCAAGCGCGATAGCCTGAATATCCGCATCAAACCGGAGGACCGGGGATTGATCGA
TCGGGCCGCCAAGCTATTGGGCAAGAACCGGACGGATTTCATGCTCGATGCGGCGCGCCGCGCCGCCGAGGAGGCGCTGC
TCGACCACGCCGTGTTCATGGTGAGCCCCGAAGCCTATGCCGAATTTCTCGCGCGTCTGGATGCGCCGCCGCAGCCCAAC
GAGCGCCTGCGAAAAACCGTGCAGACGTCCGCGCCGTGGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References