Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 50516..50957 Replicon plasmid unnamed1
Accession NZ_CP060995
Organism Acinetobacter baumannii strain CAb-65

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IAG34_RS18855 Protein ID WP_002072926.1
Coordinates 50516..50683 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAG34_RS18860 Protein ID WP_001258992.1
Coordinates 50670..50957 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAG34_RS18820 (IAG34_18810) 46904..47260 + 357 WP_000269901.1 type II toxin-antitoxin system RelE/ParE family toxin -
IAG34_RS18825 (IAG34_18815) 47253..47555 + 303 WP_001140619.1 XRE family transcriptional regulator -
IAG34_RS18830 (IAG34_18820) 47548..47775 + 228 WP_217408638.1 hypothetical protein -
IAG34_RS18835 (IAG34_18825) 47864..48091 - 228 WP_000286812.1 hypothetical protein -
IAG34_RS18840 (IAG34_18830) 48848..49393 - 546 Protein_57 IS5-like element ISAba13 family transposase -
IAG34_RS18845 (IAG34_18835) 49321..49710 - 390 WP_002072923.1 AAA family ATPase -
IAG34_RS18850 (IAG34_18840) 49898..50218 + 321 WP_000088946.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IAG34_RS18855 (IAG34_18845) 50516..50683 + 168 WP_002072926.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IAG34_RS18860 (IAG34_18850) 50670..50957 + 288 WP_001258992.1 helix-turn-helix transcriptional regulator Antitoxin
IAG34_RS18865 (IAG34_18855) 51036..51290 - 255 WP_000236586.1 hypothetical protein -
IAG34_RS18870 (IAG34_18860) 51487..52044 - 558 Protein_63 hypothetical protein -
IAG34_RS18875 (IAG34_18865) 52084..53396 - 1313 Protein_64 terminase -
IAG34_RS18880 (IAG34_18870) 53380..53921 - 542 Protein_65 DUF2280 domain-containing protein -
IAG34_RS18885 (IAG34_18875) 53981..54622 - 642 Protein_66 putative metallopeptidase -
IAG34_RS18890 (IAG34_18880) 54591..55058 - 468 WP_000378524.1 hypothetical protein -
IAG34_RS18895 55120..55573 - 454 Protein_68 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91773 91773
- inside IScluster/Tn - - 41670..49273 7603


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-48)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-90)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6362.64 Da        Isoelectric Point: 11.0180

>T171926 WP_002072926.1 NZ_CP060995:50516-50683 [Acinetobacter baumannii]
MRLKSQEGIARVMYCTLVGKRIVMLHSFVKKTQKTPKQDLNLALDRMKEVKNANT

Download         Length: 168 bp

>T171926 NZ_CP079095:c1835012-1834086 [Methylococcus sp. Mc7]
GTGAGCAGCCGGAACACCGCCGCCTCGGTCCGTGCACGACTGCTCGCCAAGGCCCGCACCGACAAGCTGGACTTCAACCT
CGTCCTCACCCGCTACGCCCTGGAGCGGCTCCTGTATCGCCTGAGTGTTTCCGCTCATGCGGATCACTTCCTGCTCAAGG
GCGCCTTGCTGTTCGATCTGTGGTTCGACATCCCGCATCGTCCGACACGCGGCGCTGACCTGCTGGGCTTCGGCTCGGCC
GAGATCCCGCAAGTCGAGGCGGCGTTCCGGGATATCTGTGCGGTGGAACTGGACGACGGCATACGCTTTCAAGCCGACTC
GGTACACGCGGAGGAGATCCGCAAGGAAGCCAACTACTCCGGTGTCCGGGTCACGCTGATCGGACTGTTGGACGGTGCAC
GATGCCACGTGCAGGTCGACGTGGGTTTCGGCGACGCCGTGACGCCCGGCCCCGAGGCCGTCGACTACCCGGTGATGCTG
CCGGACATGCCAGCCCCAAGGCTGCGCGCCTACCCCCGCTACACGGTTGTCGCCGAGAAGCTGGAGGCACTGGTGTCGCT
CGGCATCGCCAACAGCCGCATGAAGGATTACTTCGATCTCTGGATCTTGTCGCGCTACACCGACTTCGACGGCGCGCTCC
TGTGCAAGGCGATCCACGCCACCTTCGAGCGCCGCAGGACGCCGTTGCCGGAAGGCGTCCCTTTCGGCTTGAGCGACGAG
TTTGCTGAGGACCGACAGAAGCAGACCCAGTGGCAGGCATTCCTGAGGAAGAACGCCTTGGTCGAGCTTCAGCTTTCCGA
GGTCGTTGCCGGTCTGCGTGCCTTCCTGTCACTCCCGCTGGACGCGCTCCAGCAAGGTGCTGCATTTCCGCAAACATGGC
TTGCCGGGAATGGGTGGACGTCGAGCAGCGAGGAATCCAGCCGATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10563.32 Da        Isoelectric Point: 9.7308

>AT171926 WP_001258992.1 NZ_CP060995:50670-50957 [Acinetobacter baumannii]
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTALREAGLSQAQIAERMGTNVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV

Download         Length: 288 bp

>AT171926 NZ_CP079095:c1835608-1835009 [Methylococcus sp. Mc7]
ATGGAAAGCCAGCATGATGCCATCCTAGATCTAGCCCGGGCCCAAGGGCTCCTCCGCCCGCGTGATCTGACAGCCCTGGG
GCTACCCCGAGTCGCCTTGACGCGACTGGTTCGCCGTGGGCAATTGGTTCGCGTGGGGCGTGGGCTATATGCGCTACCCG
ACCGGCCGGTGTCCGAGCATGCATCGTTCGCCGAGGTTGCGCGCAAACACCCTCAAGGGATCGTGTGCCTGCTCTCGGCG
CTGCGTTTCCACAATCTCACCACCCAGTCGCCCTTCGAGGTCTGGCTCGCCATACCCAACAAGGCCCGCGCGCCGCGGAT
GGACTACCCGCCGCTGAGGATCGTCCGGTTTTCCGGTCCCGCGCTGACTGAAGGCATCGAAGCGCACATGATCGATGGTG
TTCCAGTGCGCATTACCGGGGTGGCAAAGACAGTGGCCGACTGCTTCAAGTATCGCAACAAGATCGGTCTGGATGTCGCG
CTGGAGGCGCTGCGTGATGCCTGGAAAGGAAAGCGCGTCGGCATGGACGAACTGTGGCAGTTTGCCAAGCTGTGCCGGGT
GGCCAACGTCATGCGCCCCTACTTGGAGAGCCTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References