171911

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3916511..3917052 Replicon chromosome
Accession NZ_CP060987
Organism Escherichia coli strain EC31

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag H9212_RS19100 Protein ID WP_000615983.1
Coordinates 3916774..3917052 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag H9212_RS19095 Protein ID WP_000729703.1
Coordinates 3916511..3916771 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9212_RS19075 (3912186) 3912186..3912971 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
H9212_RS19080 (3912943) 3912943..3914655 + 1713 Protein_3761 flagellar biosynthesis protein FlhA -
H9212_RS19085 (3914879) 3914879..3915376 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
H9212_RS19090 (3915552) 3915552..3916301 - 750 WP_000056849.1 C40 family peptidase -
H9212_RS19095 (3916511) 3916511..3916771 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
H9212_RS19100 (3916774) 3916774..3917052 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
H9212_RS19105 (3917208) 3917208..3917948 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
H9212_RS19110 (3917919) 3917919..3918686 - 768 WP_000333380.1 class II glutamine amidotransferase -
H9212_RS19115 (3918892) 3918892..3919470 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T171911 WP_000615983.1 NZ_CP060987:3916774-3917052 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T171911 NZ_CP078521:1833370-1833465 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT171911 WP_000729703.1 NZ_CP060987:3916511-3916771 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT171911 NZ_CP078521:c1833550-1833493 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1F716

References