171893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 721965..722658 Replicon chromosome
Accession NZ_CP060987
Organism Escherichia coli strain EC31

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9212_RS03535 Protein ID WP_000415584.1
Coordinates 721965..722261 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9212_RS03540 Protein ID WP_000650107.1
Coordinates 722263..722658 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9212_RS03500 (717053) 717053..717367 - 315 WP_000958598.1 putative quinol monooxygenase -
H9212_RS03505 (717398) 717398..717979 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9212_RS03510 (718298) 718298..718630 + 333 WP_000917685.1 DUF2645 family protein -
H9212_RS03515 (718676) 718676..720025 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
H9212_RS03520 (720022) 720022..720681 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H9212_RS03525 (720833) 720833..721225 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9212_RS03530 (721278) 721278..721760 + 483 WP_000183505.1 GyrI-like domain-containing protein -
H9212_RS03535 (721965) 721965..722261 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9212_RS03540 (722263) 722263..722658 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9212_RS03545 (722791) 722791..724398 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H9212_RS03550 (724536) 724536..726794 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T171893 WP_000415584.1 NZ_CP060987:721965-722261 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171893 NZ_CP078162:2561297-2561479 [Enterococcus faecalis]
ATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTT
GTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGC
TTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171893 WP_000650107.1 NZ_CP060987:722263-722658 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171893 NZ_CP078162:c2561596-2561412 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References