Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 61350..61614 | Replicon | plasmid pEC3-3 |
| Accession | NZ_CP060981 | ||
| Organism | Escherichia coli strain EC3 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | H9191_RS24010 | Protein ID | WP_001331364.1 |
| Coordinates | 61462..61614 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 61350..61412 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9191_RS23995 (56589) | 56589..58880 | - | 2292 | WP_001289276.1 | F-type conjugative transfer protein TrbC | - |
| H9191_RS24000 (58873) | 58873..59943 | - | 1071 | WP_000151582.1 | IncI1-type conjugal transfer protein TrbB | - |
| H9191_RS24005 (59962) | 59962..61170 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (61350) | 61350..61412 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (61350) | 61350..61412 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (61350) | 61350..61412 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (61350) | 61350..61412 | - | 63 | NuclAT_0 | - | Antitoxin |
| H9191_RS24010 (61462) | 61462..61614 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| H9191_RS24015 (61686) | 61686..61937 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| H9191_RS25055 (62436) | 62436..62531 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| H9191_RS24025 (62596) | 62596..62772 | - | 177 | WP_001054897.1 | hypothetical protein | - |
| H9191_RS24030 (63164) | 63164..63373 | + | 210 | WP_039025903.1 | HEAT repeat domain-containing protein | - |
| H9191_RS24035 (63445) | 63445..64107 | - | 663 | WP_000644796.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| H9191_RS24040 (64178) | 64178..66346 | - | 2169 | WP_000698354.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aac(3)-IId / blaCTX-M-14 | - | 1..106787 | 106787 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T171884 WP_001331364.1 NZ_CP060981:61462-61614 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T171884 NZ_CP078159:828383-828589 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCGCTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCAACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCGCTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCAACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA
Antitoxin
Download Length: 63 bp
>AT171884 NZ_CP060981:c61412-61350 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
