Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2418696..2419334 Replicon chromosome
Accession NZ_CP060979
Organism Escherichia coli strain EC3

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag H9191_RS11985 Protein ID WP_001447010.1
Coordinates 2419158..2419334 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H9191_RS11980 Protein ID WP_001270286.1
Coordinates 2418696..2419112 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9191_RS11960 (2413848) 2413848..2414789 - 942 WP_001251304.1 ABC transporter permease -
H9191_RS11965 (2414790) 2414790..2415803 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
H9191_RS11970 (2415821) 2415821..2416966 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
H9191_RS11975 (2417211) 2417211..2418617 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
H9191_RS11980 (2418696) 2418696..2419112 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H9191_RS11985 (2419158) 2419158..2419334 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H9191_RS11990 (2419556) 2419556..2419786 + 231 WP_000494244.1 YncJ family protein -
H9191_RS11995 (2419878) 2419878..2421839 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H9191_RS12000 (2421912) 2421912..2422448 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
H9191_RS12005 (2422540) 2422540..2423715 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2423755..2424903 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T171869 WP_001447010.1 NZ_CP060979:c2419334-2419158 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T171869 NZ_CP078145:c6356924-6356499 [Nocardia iowensis]
GTGAGGAACTATCTGCTCGATACGAGTGCGGTGTCGGAATGGGTGAAGCCTCGGCCGGATCCCGGCCTCACCCAATGGCT
CCACACGACTGACGAGGACCGGCTTCATCTCAGCGTCATCACCCTCGGCGAAATCCGTAAGGGCATCGAGAAGATGCCGG
ATTCGCCCAAGAAGCGGCGGCTGGTGGAGTGGCTGACGGAATCGCTGATCGACCGGTTCGAAGGGCGCCTCCTGTCGGTA
GACGCGACAGTCGCACAAGCATGGGGACGGATGGTTGCGCGAACTGAAGGGAACGGAAATCCGGTCGAGCCGGCGGACGC
GCTGATCGCGGCGACCGCCGTATCGCACGGGCTGGAGGTTGTCACGCGGAATGTCGGACATTTCGGACCGACCGGGGTGG
CGATCGTATGTCCCTGGCACGGCTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT171869 WP_001270286.1 NZ_CP060979:c2419112-2418696 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT171869 NZ_CP078145:c6357217-6356921 [Nocardia iowensis]
GTGGTCGAAACGGGTGATCAGATGGCTCGAAAGCGGTCGGAGCGACCTGACGTCGCATGGCCACTTGCCGACGCGAAGGC
CAGGTTGTCCGAGTTGATCGACATCGTCGAGCGGGAGGGGCCGCAAGTGATCAGCAAGCATGGACGAGAGGTCGCTGTTG
TCGTACCGATCGACGAGTGGCGGCAGAAAACGAGCAGGCAGGGGAGCCTCGCCGAGTTCTTCGCGGCTTCGCCGCTGCGC
GATTCCGGAGTAGAGATCGAACGCATCCATATGGATGTCCGTGACGTCGAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References