Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 724850..725543 Replicon chromosome
Accession NZ_CP060979
Organism Escherichia coli strain EC3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9191_RS03545 Protein ID WP_000415584.1
Coordinates 724850..725146 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9191_RS03550 Protein ID WP_000650107.1
Coordinates 725148..725543 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9191_RS03510 (719938) 719938..720252 - 315 WP_000958598.1 putative quinol monooxygenase -
H9191_RS03515 (720283) 720283..720864 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9191_RS03520 (721183) 721183..721515 + 333 WP_000917684.1 DUF2645 family protein -
H9191_RS03525 (721561) 721561..722910 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
H9191_RS03530 (722907) 722907..723566 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H9191_RS03535 (723718) 723718..724110 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9191_RS03540 (724163) 724163..724645 + 483 WP_000183505.1 GyrI-like domain-containing protein -
H9191_RS03545 (724850) 724850..725146 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9191_RS03550 (725148) 725148..725543 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9191_RS03555 (725676) 725676..727283 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H9191_RS03560 (727421) 727421..729679 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T171854 WP_000415584.1 NZ_CP060979:724850-725146 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171854 NZ_CP078140:22059-22385 [Pseudomonas savastanoi pv. savastanoi]
ATGATGCGAGGTGACCTAGTCACCGTCGCCATGCAAGGTGACTTTGGTAAACCAAGACCCGCCTTGGTAATTCAGGCAAA
CCAATTCAGCGAACACACCAGCGTTACCGTGCTGCCAGTGACCAGCACCCTAGTCGCAGCACCGCTGCTGCGCATCACCG
TTCAGCCGACCGCAGAAAACGGCTTGCAGAAGCCTTCTCAGGTCATGCTAGACAAGACCATGACACTCAAGCGTGAAAAA
ATAGGCCCGACTTTTGGGCATATCGGAGTGGATTCAATGGTGGAGGTGGAGCGCTGTTTAGCCGTGTTCTTGGGTATCGC
CAATTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171854 WP_000650107.1 NZ_CP060979:725148-725543 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171854 NZ_CP078140:21838-22062 [Pseudomonas savastanoi pv. savastanoi]
ATGCCTACATCCCATGTAAATGACCGCGTTCAACGCCATCGCGACGCGCTGCGTGCGGCTGGCCTACGGCCCATTCAGAT
TTGGGTTCCCGATACCCGGCGGCCAGACTTTGCACAGGAGTGCCATCGACAGTGCCTGTTGGTTGCTCAGGCAGACATGG
CCAATACCTATATGCAGGGGTTGATGGACGAAGCCTTAGACGATGTTGAGGGTTGGACGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References