Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 83916..84342 | Replicon | plasmid pEC4-2 |
| Accession | NZ_CP060975 | ||
| Organism | Escherichia coli strain EC4 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | H9192_RS24060 | Protein ID | WP_001372321.1 |
| Coordinates | 83916..84041 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 84118..84342 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9192_RS24020 (79290) | 79290..79979 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| H9192_RS24025 (80166) | 80166..80549 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| H9192_RS24030 (80870) | 80870..81472 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| H9192_RS24035 (81769) | 81769..82590 | - | 822 | WP_241461981.1 | DUF932 domain-containing protein | - |
| H9192_RS24040 (82708) | 82708..82995 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| H9192_RS24045 (83020) | 83020..83226 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| H9192_RS24050 (83296) | 83296..83468 | + | 173 | Protein_102 | hypothetical protein | - |
| H9192_RS24055 (83466) | 83466..83696 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| H9192_RS24060 (83916) | 83916..84041 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| H9192_RS24065 (83983) | 83983..84132 | - | 150 | Protein_105 | plasmid maintenance protein Mok | - |
| - (84118) | 84118..84342 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (84118) | 84118..84342 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (84118) | 84118..84342 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (84118) | 84118..84342 | - | 225 | NuclAT_0 | - | Antitoxin |
| H9192_RS24070 (84154) | 84154..84342 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| H9192_RS24075 (84311) | 84311..85073 | - | 763 | Protein_107 | plasmid SOS inhibition protein A | - |
| H9192_RS24080 (85070) | 85070..85504 | - | 435 | WP_241461975.1 | conjugation system SOS inhibitor PsiB | - |
| H9192_RS24085 (85559) | 85559..85756 | - | 198 | Protein_109 | hypothetical protein | - |
| H9192_RS24090 (85784) | 85784..86017 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| H9192_RS24095 (86085) | 86085..86624 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| H9192_RS24100 (86650) | 86650..86856 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| H9192_RS24105 (86926) | 86926..87006 | + | 81 | Protein_113 | hypothetical protein | - |
| H9192_RS24110 (87189) | 87189..87358 | - | 170 | Protein_114 | hypothetical protein | - |
| H9192_RS24115 (87995) | 87995..88966 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-14 / qacE / cmlA1 / mph(A) / oqxB / oqxA / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..112054 | 112054 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T171847 WP_001372321.1 NZ_CP060975:c84041-83916 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T171847 NZ_CP078139:160867-161286 [Pseudomonas savastanoi pv. savastanoi]
ATGATCCTGCTCGATACGAACGTAATTTCAGAACCGCAGCGCCGAGAGCCCAATGCCCACGTCCTTGACTGGATCGACGC
ACAAGCGCTGGAAACGCTTTATCTGTCCACCATCACCGTAGCCGAGTTGCGTGCAGGTATCGCGCTGATGCCTGTCGGAA
AACGCCAGGATAGCTTGCGTGAAAACCTGGAAAAGCACCTGCTGCCGATGTTCGCCAATAGGGTGCTGTCGTTCGATATG
ACTTGTACGAAGGCTTATGCCGAGCTGCTGGCCAAGTCCCGCGCAGCCGGGTTGGCGGTCGAAACGGCAGATGCCTTCAT
TGCAGCCATCGCCCTCGCCAACGGCTTCACCGTCGCCACCCGTGACACTGGCCCTTTTGAGGCTGCCGGGTTGAACGTCA
TTAACCCCTGGGAAACGTAA
ATGATCCTGCTCGATACGAACGTAATTTCAGAACCGCAGCGCCGAGAGCCCAATGCCCACGTCCTTGACTGGATCGACGC
ACAAGCGCTGGAAACGCTTTATCTGTCCACCATCACCGTAGCCGAGTTGCGTGCAGGTATCGCGCTGATGCCTGTCGGAA
AACGCCAGGATAGCTTGCGTGAAAACCTGGAAAAGCACCTGCTGCCGATGTTCGCCAATAGGGTGCTGTCGTTCGATATG
ACTTGTACGAAGGCTTATGCCGAGCTGCTGGCCAAGTCCCGCGCAGCCGGGTTGGCGGTCGAAACGGCAGATGCCTTCAT
TGCAGCCATCGCCCTCGCCAACGGCTTCACCGTCGCCACCCGTGACACTGGCCCTTTTGAGGCTGCCGGGTTGAACGTCA
TTAACCCCTGGGAAACGTAA
Antitoxin
Download Length: 225 bp
>AT171847 NZ_CP060975:c84342-84118 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
