Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 35159..35413 | Replicon | plasmid pEC4-2 |
| Accession | NZ_CP060975 | ||
| Organism | Escherichia coli strain EC4 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | H9192_RS23770 | Protein ID | WP_001312851.1 |
| Coordinates | 35159..35308 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 35352..35413 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9192_RS23725 (30722) | 30722..31123 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| H9192_RS23730 (31056) | 31056..31313 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| H9192_RS23735 (31406) | 31406..31714 | - | 309 | WP_226116723.1 | CPBP family intramembrane metalloprotease | - |
| H9192_RS23740 (31656) | 31656..32048 | - | 393 | WP_000616804.1 | histidine phosphatase family protein | - |
| H9192_RS23745 (32987) | 32987..33844 | - | 858 | WP_000774297.1 | incFII family plasmid replication initiator RepA | - |
| H9192_RS23750 (33837) | 33837..34319 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| H9192_RS23755 (34312) | 34312..34359 | - | 48 | WP_229471593.1 | hypothetical protein | - |
| H9192_RS23760 (34350) | 34350..34601 | + | 252 | WP_223195197.1 | replication protein RepA | - |
| H9192_RS23765 (34618) | 34618..34875 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| H9192_RS23770 (35159) | 35159..35308 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (35352) | 35352..35413 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (35352) | 35352..35413 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (35352) | 35352..35413 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (35352) | 35352..35413 | + | 62 | NuclAT_1 | - | Antitoxin |
| H9192_RS23775 (35669) | 35669..35743 | - | 75 | Protein_47 | endonuclease | - |
| H9192_RS23780 (35989) | 35989..36201 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| H9192_RS23785 (36337) | 36337..36897 | - | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
| H9192_RS23790 (37000) | 37000..37860 | - | 861 | WP_000704514.1 | alpha/beta hydrolase | - |
| H9192_RS23795 (37919) | 37919..38665 | - | 747 | WP_000205749.1 | conjugal transfer pilus acetylase TraX | - |
| H9192_RS23800 (38685) | 38685..38933 | - | 249 | WP_241461978.1 | protein traI | - |
| H9192_RS23805 (38958) | 38958..39662 | + | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| H9192_RS23810 (39714) | 39714..40136 | - | 423 | Protein_54 | recombinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-14 / qacE / cmlA1 / mph(A) / oqxB / oqxA / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..112054 | 112054 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T171842 WP_001312851.1 NZ_CP060975:c35308-35159 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T171842 NZ_CP078137:3150303-3150581 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 62 bp
>AT171842 NZ_CP060975:35352-35413 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
