Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3754392..3755086 Replicon chromosome
Accession NZ_CP060969
Organism Escherichia coli strain EC5

Toxin (Protein)


Gene name yafO Uniprot ID S1EXB8
Locus tag H9193_RS18290 Protein ID WP_001263493.1
Coordinates 3754392..3754790 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag H9193_RS18295 Protein ID WP_000554757.1
Coordinates 3754793..3755086 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3750052) 3750052..3750132 - 81 NuclAT_11 - -
- (3750052) 3750052..3750132 - 81 NuclAT_11 - -
- (3750052) 3750052..3750132 - 81 NuclAT_11 - -
- (3750052) 3750052..3750132 - 81 NuclAT_11 - -
H9193_RS18260 (3749392) 3749392..3750636 - 1245 WP_000189541.1 esterase FrsA -
H9193_RS18265 (3750728) 3750728..3751186 - 459 WP_061349133.1 xanthine phosphoribosyltransferase -
H9193_RS18270 (3751447) 3751447..3752904 + 1458 WP_001293003.1 cytosol nonspecific dipeptidase -
H9193_RS18275 (3752961) 3752961..3753482 - 522 Protein_3596 peptide chain release factor H -
H9193_RS18280 (3753481) 3753481..3753684 - 204 Protein_3597 RtcB family protein -
H9193_RS18285 (3753930) 3753930..3754382 - 453 WP_001059847.1 GNAT family N-acetyltransferase -
H9193_RS18290 (3754392) 3754392..3754790 - 399 WP_001263493.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
H9193_RS18295 (3754793) 3754793..3755086 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
H9193_RS18300 (3755138) 3755138..3756193 - 1056 WP_001226164.1 DNA polymerase IV -
H9193_RS18305 (3756264) 3756264..3757049 - 786 WP_000207564.1 putative lateral flagellar export/assembly protein LafU -
H9193_RS18310 (3757021) 3757021..3758733 + 1713 Protein_3603 flagellar biosynthesis protein FlhA -
H9193_RS18315 (3758957) 3758957..3759454 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-130)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 15472.83 Da        Isoelectric Point: 8.0949

>T171798 WP_001263493.1 NZ_CP060969:c3754790-3754392 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T171798 NZ_CP078120:c2820587-2820318 [Halomonas sp. 18071143]
ATGCCGGAAATTGATGCGTTGCTCGGCCTTTCTTTTTGCTTGTATTTTTTTGATAACAAGCAACATAAGCTACCCCACCT
TCATGTGAAGTATGGTAGCTACGAACTGATCATTGCGATTGAAACGGGTGAGTGCCTGGAGGGCTATCTACCTAACAAGC
AGCGTAAGAGAGCGGAGAGCCATATTTTCGATCACCGTGAACAGTTGATGGTGATGTGGCACAAAGCAGTGAATGGCGAA
AACCCGGGTAAGCTAGGTGACGTATGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT171798 WP_000554757.1 NZ_CP060969:c3755086-3754793 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT171798 NZ_CP078120:c2820324-2819803 [Halomonas sp. 18071143]
ATGCTAAAAATCGTGGATGTTGATGTCATTTCAGGTCATGCCTTGGCGCTAACGTTCAGCGATGGCTACTTCGGCCGCGC
TGATCTGACAGCTTACTTCAGTAAGCCTCCCTTTTCTGAGATCAAGGATTTCAAGCGTTTTTCCTTAACACCAGAAGGAT
CCCTCAATTGGAGCGGCAACGAGCTTTCTGCGGCAACACTGCGTGCTATTACCAAAGGTGAGCAAAAATCCGCAGACGTT
TTTGTTAACGTTCAAGAAATGGAAGCCGTCATTAAGCAGGCTTCCTGGGAGTCGATGAAAGAGGGACGCGCCGATATTTT
GCAAGCCGCCATTCGCTCTTATGTGGAACAATTTGGTCATAGTCAAGTGATTGCGAAAGCAGGTATCAAAAGTCGCACCA
GTGCTTATCGTTCCTTAAAACCTGAAACCAGGCCCAATTTTGATACGTTGGTTCAACTGGGGCACGCAGTGATTGAGCTC
GCGCAAGAGCGTGCTGTCAGTATCAACGAGTCTTCCATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1EXB8


Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References