Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 799804..800497 Replicon chromosome
Accession NZ_CP060969
Organism Escherichia coli strain EC5

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9193_RS03905 Protein ID WP_000415584.1
Coordinates 799804..800100 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9193_RS03910 Protein ID WP_000650107.1
Coordinates 800102..800497 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9193_RS03870 (794892) 794892..795206 - 315 WP_000958598.1 putative quinol monooxygenase -
H9193_RS03875 (795237) 795237..795818 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9193_RS03880 (796137) 796137..796469 + 333 WP_000917684.1 DUF2645 family protein -
H9193_RS03885 (796515) 796515..797864 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
H9193_RS03890 (797861) 797861..798520 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H9193_RS03895 (798672) 798672..799064 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9193_RS03900 (799117) 799117..799599 + 483 WP_000183505.1 GyrI-like domain-containing protein -
H9193_RS03905 (799804) 799804..800100 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9193_RS03910 (800102) 800102..800497 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9193_RS03915 (800630) 800630..802237 + 1608 WP_064221462.1 ABC transporter substrate-binding protein -
H9193_RS03920 (802375) 802375..804633 + 2259 WP_072649944.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T171781 WP_000415584.1 NZ_CP060969:799804-800100 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171781 NZ_CP078116:c863918-863499 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171781 WP_000650107.1 NZ_CP060969:800102-800497 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171781 NZ_CP078116:c864154-863918 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References