Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 102623..103049 | Replicon | plasmid pEC7-2 |
| Accession | NZ_CP060964 | ||
| Organism | Escherichia coli strain EC7 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | H9194_RS24405 | Protein ID | WP_001372321.1 |
| Coordinates | 102623..102748 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 102825..103049 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9194_RS24365 (97997) | 97997..98686 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| H9194_RS24370 (98873) | 98873..99256 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| H9194_RS24375 (99577) | 99577..100179 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| H9194_RS24380 (100476) | 100476..101297 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| H9194_RS24385 (101415) | 101415..101702 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| H9194_RS24390 (101727) | 101727..101933 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| H9194_RS24395 (102003) | 102003..102175 | + | 173 | Protein_106 | hypothetical protein | - |
| H9194_RS24400 (102173) | 102173..102403 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| H9194_RS24405 (102623) | 102623..102748 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| H9194_RS24410 (102690) | 102690..102839 | - | 150 | Protein_109 | plasmid maintenance protein Mok | - |
| - (102825) | 102825..103049 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (102825) | 102825..103049 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (102825) | 102825..103049 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (102825) | 102825..103049 | - | 225 | NuclAT_0 | - | Antitoxin |
| H9194_RS24415 (102861) | 102861..103049 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| H9194_RS24420 (103018) | 103018..103780 | - | 763 | Protein_111 | plasmid SOS inhibition protein A | - |
| H9194_RS24425 (103777) | 103777..104211 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| H9194_RS24430 (104266) | 104266..104463 | - | 198 | Protein_113 | hypothetical protein | - |
| H9194_RS24435 (104491) | 104491..104724 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| H9194_RS24440 (104792) | 104792..105331 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| H9194_RS24445 (105357) | 105357..105563 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| H9194_RS24450 (105633) | 105633..105713 | + | 81 | Protein_117 | hypothetical protein | - |
| H9194_RS24455 (105896) | 105896..106065 | - | 170 | Protein_118 | hypothetical protein | - |
| H9194_RS24460 (106702) | 106702..107673 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-14 / fosA3 / aac(3)-IVa / sul2 / floR / oqxA / oqxB / sitABCD | iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA | 1..128054 | 128054 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T171770 WP_001372321.1 NZ_CP060964:c102748-102623 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T171770 NZ_CP078110:3704478-3704753 [Cronobacter sakazakii]
ATGAAGCTGACCGAATACGATCCCGCAGCGGCGCTGGTAGATGATGAGGAGATCGCCTTCTTTATGGCGGACGCGCTCGA
AACTGGCGACGCCGGACATATTGCAAAGGCGCTGGGCGTCGTCGCGCGCGCTAAAGGCATGTCGCATATCGCCGCTCAGA
CAGGGCTGTCGCGTGAACAGCTGTACCGTTCTTTCAGTGATAAAGGCAACCCAACGCTTAAAACCACGCTGGCAGTGATG
AAAGCGTTGGGTCTCGGTTTAACGGTTAAATCATAA
ATGAAGCTGACCGAATACGATCCCGCAGCGGCGCTGGTAGATGATGAGGAGATCGCCTTCTTTATGGCGGACGCGCTCGA
AACTGGCGACGCCGGACATATTGCAAAGGCGCTGGGCGTCGTCGCGCGCGCTAAAGGCATGTCGCATATCGCCGCTCAGA
CAGGGCTGTCGCGTGAACAGCTGTACCGTTCTTTCAGTGATAAAGGCAACCCAACGCTTAAAACCACGCTGGCAGTGATG
AAAGCGTTGGGTCTCGGTTTAACGGTTAAATCATAA
Antitoxin
Download Length: 225 bp
>AT171770 NZ_CP060964:c103049-102825 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
