Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2365538..2367126 | Replicon | chromosome |
Accession | NZ_CP060963 | ||
Organism | Escherichia coli strain EC7 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | S1ELM3 |
Locus tag | H9194_RS11715 | Protein ID | WP_001125439.1 |
Coordinates | 2365804..2367126 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | H9194_RS11710 | Protein ID | WP_001301023.1 |
Coordinates | 2365538..2365804 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H9194_RS11710 (2365538) | 2365538..2365804 | + | 267 | WP_001301023.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
H9194_RS11715 (2365804) | 2365804..2367126 | + | 1323 | WP_001125439.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
H9194_RS11720 (2367438) | 2367438..2367646 | + | 209 | Protein_2300 | AraC family transcriptional regulator | - |
H9194_RS11725 (2367901) | 2367901..2369127 | + | 1227 | Protein_2301 | fimbria/pilus outer membrane usher protein | - |
H9194_RS11730 (2369141) | 2369141..2369671 | + | 531 | WP_000876763.1 | fimbrial protein | - |
H9194_RS11735 (2369684) | 2369684..2370187 | + | 504 | WP_000825452.1 | fimbrial protein | - |
H9194_RS11740 (2370246) | 2370246..2371160 | + | 915 | WP_000520662.1 | fimbrial protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 2365538..2378347 | 12809 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49275.82 Da Isoelectric Point: 8.2482
>T171761 WP_001125439.1 NZ_CP060963:2365804-2367126 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
Download Length: 1323 bp
>T171761 NZ_CP078110:1604585-1604881 [Cronobacter sakazakii]
ATGCAAAAGCATATCGGCAGTTTTCGTGACGCCTGGCTGGCGGCGTTTTTCGTGTATTCGACGCCACACCGCAACATCCC
GGCGGAGATTCATACCACACTGGCGCGCAAGCTCGACATCATCAACGCAGCAACGTCATACCGCGATCTCCGCTCGCCGC
CTGGCAACCGCTTTGAGGCGCTGAGCGGTAAATTGCAGGGGTATTCATCGATTCGGGTCAACCATCACTACCGCCTGATT
TTCAGATGGGTGGAAGGCAAAGCGGAAGATCTCTATTTAGATCCGCATGATTACTGA
ATGCAAAAGCATATCGGCAGTTTTCGTGACGCCTGGCTGGCGGCGTTTTTCGTGTATTCGACGCCACACCGCAACATCCC
GGCGGAGATTCATACCACACTGGCGCGCAAGCTCGACATCATCAACGCAGCAACGTCATACCGCGATCTCCGCTCGCCGC
CTGGCAACCGCTTTGAGGCGCTGAGCGGTAAATTGCAGGGGTATTCATCGATTCGGGTCAACCATCACTACCGCCTGATT
TTCAGATGGGTGGAAGGCAAAGCGGAAGATCTCTATTTAGATCCGCATGATTACTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10016.38 Da Isoelectric Point: 6.2267
>AT171761 WP_001301023.1 NZ_CP060963:2365538-2365804 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW
Download Length: 267 bp
>AT171761 NZ_CP078110:1604914-1605255 [Cronobacter sakazakii]
ATGAAACAGGCAACCAGAAAGCCCACGACGCCCGGCGAGATCCTGGTGAACGAATACCTGGAGCCGCTCGGCCTTAAAAT
CAACGAGGTGGCGGAGATGCTTTGCGTCCATCGTAATAGCGTGAGCGCGCTGGTGAACAATAACCGCAAACTCACTACAG
ATATGGCGTTTCGTCTGGCAAAAGCGTTTGGAACCTCAGTTGATTTCTGGCTTAACCTGCAGGCGGCTGTCGATCTGTGG
GAGGTCGAGAATGATATGCGCATTCAGGAAGCGTTCAGCCGCATCGTACCCGCTGCGGAGTTTATCGCCCGGCGCGACGC
GCAGAAGAAAGCTGGCGCCTGA
ATGAAACAGGCAACCAGAAAGCCCACGACGCCCGGCGAGATCCTGGTGAACGAATACCTGGAGCCGCTCGGCCTTAAAAT
CAACGAGGTGGCGGAGATGCTTTGCGTCCATCGTAATAGCGTGAGCGCGCTGGTGAACAATAACCGCAAACTCACTACAG
ATATGGCGTTTCGTCTGGCAAAAGCGTTTGGAACCTCAGTTGATTTCTGGCTTAACCTGCAGGCGGCTGTCGATCTGTGG
GAGGTCGAGAATGATATGCGCATTCAGGAAGCGTTCAGCCGCATCGTACCCGCTGCGGAGTTTATCGCCCGGCGCGACGC
GCAGAAGAAAGCTGGCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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