Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3942133..3942827 Replicon chromosome
Accession NZ_CP060953
Organism Escherichia coli strain EC8

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag H9195_RS19060 Protein ID WP_001263500.1
Coordinates 3942429..3942827 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag H9195_RS19055 Protein ID WP_000554758.1
Coordinates 3942133..3942426 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9195_RS19030 (3937950) 3937950..3938417 + 468 WP_000725261.1 flagellar basal body-associated FliL family protein -
H9195_RS19035 (3938437) 3938437..3939153 + 717 WP_000938731.1 FliA/WhiG family RNA polymerase sigma factor -
H9195_RS19040 (3939166) 3939166..3940029 + 864 WP_001169518.1 flagellar motor stator protein MotA -
H9195_RS19045 (3940032) 3940032..3940955 + 924 WP_001532973.1 putative lateral flagellar export/assembly protein LafU -
H9195_RS19050 (3941026) 3941026..3942081 + 1056 WP_001226168.1 DNA polymerase IV -
H9195_RS19055 (3942133) 3942133..3942426 + 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
H9195_RS19060 (3942429) 3942429..3942827 + 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
H9195_RS19065 (3942837) 3942837..3943289 + 453 WP_001059895.1 GNAT family N-acetyltransferase -
H9195_RS19070 (3943479) 3943479..3944618 + 1140 WP_000521561.1 RNA ligase RtcB family protein -
H9195_RS19075 (3944615) 3944615..3945229 + 615 WP_000602124.1 peptide chain release factor H -
H9195_RS19080 (3945286) 3945286..3946743 - 1458 WP_001292999.1 cytosol nonspecific dipeptidase -
H9195_RS19085 (3947004) 3947004..3947462 + 459 WP_001291991.1 xanthine phosphoribosyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-130)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T171740 WP_001263500.1 NZ_CP060953:3942429-3942827 [Escherichia coli]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T171740 NZ_CP078071:1289702-1290283 [Burkholderia sp. EMB26]
ATGAATCCCGATACGATCCGCGCGCGCCTCGATTTCCTGCGCGACGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTATGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCCGACAAGAGCGCGCACGAACGCGACGATCTGCTGACGCTGACCGCGTCGCTCGACCG
CGCGGTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCACCCGAAGCCCGCGCGGCGAAGGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGCGCGATCCGCGAGATCGTCGATGTCGACACGCAGCGCAGGATCGA
CGCGGGTGGGCAGCGCGCGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT171740 WP_000554758.1 NZ_CP060953:3942133-3942426 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT171740 NZ_CP078071:1289057-1289623 [Burkholderia sp. EMB26]
ATGCCCCACCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCATGCAGCCGAACTGTTCCGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTGATCGCCGGC
AGCACGGGCCGCATGCATCTCGTGTGCGACTTCACGCACCGCCTGCTGGCCAGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCGGCCGCTTTCGACGCTGCTCGGCGCGTCGCTGTGGCGCTACGCGACGCCGGAAATCGCCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGTACGACCGCGCGGGACCGCCGAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCTGTGCCGATGGACGCGGATGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAAACGCTGGACGC
GCACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PJQ2


Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References