Detailed information of TA system TA171737

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3630778..3631036
• Replicon: chromosome
• Accession: NZ_CP060953
• Organism: Escherichia coli strain EC8

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: H9195_RS17580
• Protein ID: WP_000809168.1
• Coordinates: 3630778..3630930 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3630979..3631036 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9195_RS17560	3626023..3626736	-	714	WP_001102391.1	acidic protein MsyB	-
H9195_RS17565	3626762..3627166	-	405	WP_000843687.1	DUF2541 family protein	-
H9195_RS17570	3627538..3629454	+	1917	WP_000516135.1	molecular chaperone DnaK	-
H9195_RS17575	3629543..3630673	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
H9195_RS17580	3630778..3630930	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3630979..3631036	+	58	-	-	Antitoxin
H9195_RS17585	3631545..3632306	+	762	WP_001274832.1	outer membrane protein OmpK	-
H9195_RS17590	3632326..3633819	+	1494	WP_001774152.1	sulfatase-like hydrolase/transferase	-
H9195_RS17595	3633948..3635207	+	1260	WP_000494929.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T171737 WP_000809168.1 NZ_CP060953:c3630930-3630778 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T171737 NZ_CP078070:1861220-1861519 [Burkholderia sp. EMB26]
ATGGCGGTTAAAGGCAGACAACTTCGGCTGACCCCGTTGGCTGAATGCGATCTTGAAGACATTTGGCGCTATACCGCCGA
GCATTGGTCGCCCGAGCAGGCAGAGCACTATTACCGCGATCTGATTGGCACCATGGAAGCGCTGGCGCGCGGCAAAAAAG
CGGGGCGGATTTGCGTTGTTCGCGACGGATATTTTCGCTACCCCGCTGGTTCTCACGTTGTGTTCTATCGCGAAACGGAT
GAAACCATCGACGTCATCCGTGTCCTGCATCAACGGATGGACATCGAACGACATCTGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT171737 NZ_CP060953:3630979-3631036 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin