171726

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1994928..1995621 Replicon chromosome
Accession NZ_CP060953
Organism Escherichia coli strain EC8

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9195_RS09700 Protein ID WP_000415584.1
Coordinates 1995325..1995621 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9195_RS09695 Protein ID WP_000650107.1
Coordinates 1994928..1995323 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9195_RS09685 (1990792) 1990792..1993050 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
H9195_RS09690 (1993188) 1993188..1994795 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H9195_RS09695 (1994928) 1994928..1995323 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9195_RS09700 (1995325) 1995325..1995621 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9195_RS09705 (1995826) 1995826..1996308 - 483 WP_000183505.1 GyrI-like domain-containing protein -
H9195_RS09710 (1996361) 1996361..1996753 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9195_RS09715 (1996905) 1996905..1997564 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H9195_RS09720 (1997561) 1997561..1998910 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
H9195_RS09725 (1998956) 1998956..1999288 - 333 WP_000917685.1 DUF2645 family protein -
H9195_RS09730 (1999607) 1999607..2000188 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9195_RS09735 (2000219) 2000219..2000533 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1986465..1995621 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T171726 WP_000415584.1 NZ_CP060953:c1995621-1995325 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171726 NZ_CP078069:255306-255608 [Comamonas sp. NLF-1-9]
ATGGAACCCCTCAAACTGCGCAGGTGGGACAGCGCGGAGCATCTCAAGACCGAAGAGGACATGGTGCTGTATCTGCAAGC
CTGCATGGAAGAGGCGGGAGACGACGCCGCCTTCATCGCCAAGGCGCTTGGCAATGTCGCCCGCGCCCGTGGCATGACCC
AGCTCGCCAAGGAGACCGGTCTGGGCCGCGAAAGCCTCTACAAGGCGCTGTCGGGCGAAGGCAACCCGAGCTTTGGCACG
ATCCTCAAGGTCATGCACGCGCTGGGCATCAAGCTGCAGGCCCAGGCAGCGGACCCAGCCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171726 WP_000650107.1 NZ_CP060953:c1995323-1994928 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171726 NZ_CP078069:255000-255290 [Comamonas sp. NLF-1-9]
ATGTTGGTCATCCACACCACTGAGACATTCGACCGCTGGTTCGAATCCCTGCGCGACAGGCGCGCGGCGCAACGTATACA
GGCGCGTATCGACCGGGCAGAAGACGGGAATTTCGGCGATTGCGAGCCCATTGGTGAGGGCGTCTCGGAAATGCGGATCC
ACCACGGCCCCGGCTATCGGGTTTATTTTGTGGGGCGCGGTATGGAGGTCGTGATCTTGCTGGCAGGCGGCAACAAAGCC
AGCCAAGGCAAGGACATCAAGACCGCCTTGGAACTGGCGCGACGACTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References